Skip Navigation

Faculty Directory

Wayne Mitzner, PhD

  • Co-Director, Toxicology, Physiology, & Molecular Mechanisms
  • Professor

Departmental Affiliations

Contact Information

E-7608
Baltimore, Maryland

410 614 5446
410 955 0299

Mitzner Lab: http://www.jhsph.edu/departments/environmental-health-sciences/mitzner/index.html
PhD Program: http://www.ephysiology.org

SciVal Experts Research Profile

Education

PhD, Johns Hopkins University, 1972

Overview

Brief description of current research activities:

My research interests are focused on the structural basis of physiologic lung function and how this normal structure manifests itself in pathologic situations and environmental exposures.   Current work is concerned with understanding the mechanisms that underlie the chronic lung tissue destruction that occurs in emphysema.  These functional and immunological studies in the mouse are directed toward investigating mechanisms of alveolar destruction with age or with emphysematous lesions.  How this tissue destruction impacts the interaction between the lung parenchyma and airways plays a key role in the ability to breath in this pathology, and ongoing work is involved in studying this interaction.  Additional funded work involves evaluating methods of impairing the ability of airway smooth muscle to shorten, as a possible treatment of asthma.  The approach, termed bronchial thermoplasty, has direct clinical implications for the most severe asthmatic subjects.   I also have a keen interest in understanding and developing methods to properly phenotype pulmonary function in the mouse, which is the most common experimental animal model of most human diseases.  I’ve chaired several minisymposia and postgraduate courses in this area of mouse phenotyping.   

Honors and Awards

Member of Tau Beta Pi, Eta Kappa Nu, & Sigma XI Honor Societies

1975 - 1978. Recipient of Young Investigator Pulmonary Research Grant

1978 - 1982. Recipient of NIH Research Career Development Award 

1983 - 1993. Editorial Board of American Review of Respiratory Disease

1983 - present.  Editorial Board of Journal of Applied Physiology

1996  Elected to the College of Fellows of the American Institute of Medical and Biological Engineering

2000. Distinguished Service Award from the American Lung Association of Maryland.

2006. Joseph Rodarte Award for Achievements in Respiratory Medicine and Physiology, awarded by the American Thoracic Society

2006 - 2008.  Chair of Respiratory Structure & Function Assembly of the American Thoracic Society.

2007 - 2009.  Chair of NIH study section on Respiratory integrative Biology and Translation

2010 - present. Consulting Editor, Journal of Applied Physiology

  • My research interests are focused on the structural basis of physiologic lung function and how this normal structure manifests itself in pathologic situations and environmental exposures.  
  • Current work is concerned with understanding the mechanisms that underlie the chronic lung tissue destruction that occurs in emphysema.  
  • These functional and immunological studies in the mouse are directed toward investigating mechanisms of alveolar destruction with age or with emphysematous lesions. 
  • How this tissue destruction impacts the interaction between the lung parenchyma and airways plays a key role in the ability to breath in this pathology, and ongoing work is involved in studying this interaction.  
  • My lab also has keen interest in the mechanisms by which airway smooth muscle contracts excessively in the pathology of asthma. 
  • Several studies in mice with hyper...
    • Limjunyawong N, Fallica J, Horton MR, Mitzner W. Measurement of the pressure-volume curve in mouse lungs. Journal of visualized experiments : JoVE2015:52376.
    • Limjunyawong N, Fallica J, Ramakrishnan A, Datta K, Gabrielson M, Horton M, Mitzner W. Phenotyping mouse pulmonary function in vivo with the lung diffusing capacity. Journal of visualized experiments : JoVE2015:e52216.
    • Limjunyawong N, Kearson A, Das S, Mitzner W. Effect of point sampling density in quantifying mouse lung emphysema. Anat Rec (Hoboken) 2015;298:531-537.
    • Brown RH, Wise R, Kirk G, Drummond B, Mitzner W. Lung density changes with growth and inflation. Chest 2015; (in press).
    • Alder JK, Barkauskas CE, Limjunyawong N, Stanley SE, Kembou F, Tuder RM, Hogan BL, Mitzner W, Armanios M. Telomere dysfunction causes alveolar stem cell failure.Proceedings of the National Academy of Sciences of the United States of America 2015;112:5099-5104.
    • Zhao H, Chan-Li Y, Collins SL, Zhang Y, Hallowell RW, Mitzner W, Horton MR. Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis. BMC pulmonary medicine 2014;14:64.
    • Limjunyawong N, Mitzner W, Horton MR. A mouse model of chronic idiopathic pulmonary fibrosis. Physiological reports 2014;2:e00249.
    • Shang Y, Das S, Rabold R, Sham JS, Mitzner W, Tang WY. Epigenetic alterations by DNA methylation in house-dust-mite induced airway hyperresponsiveness. American journal of respiratory cell and molecular biology 2013.
    • Das S, Macdonald K, Chang HY, Mitzner W. A simple method of mouse lung intubation. Journal of visualized experiments : JoVE 2013.
    • Craig JM, Scott AL, Mitzner W. Elastase-coupled beads as a tool for characterizing localized alveolar tissue destruction associated with the onset of emphysema. J Appl Physiol 2013.
    • Smaldone GC, Mitzner W. Viewpoint: Unresolved mysteries. J Appl Physiol 2012;113:1945-1947.
    • Bennett BA, Mitzner W, Tankersley CG. The effects of age and carbon black on airway resistance in mice. Inhalation toxicology 2012;24:931-938. American journal of pathology 2012;180:562-574.
    • Mitzner W. Emphysema--a disease of small airways or lung parenchyma? The New England journal of medicine2011;365:1637-1639.
    • Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, Armanios M. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med2011;184:904-912.
    • McGrath-Morrow SA, Lauer T, Collaco JM, Yee M, O'Reilly M, Mitzner W, Neptune E, Wise R, Biswal S. Neonatal hyperoxia contributes additively to cigarette smoke-induced chronic obstructive pulmonary disease changes in adult mice. American journal of respiratory cell and molecular biology 2011;45:610-616.
    • Fallica J, Das S, Horton M, Mitzner W. Application of carbon monoxide diffusing capacity in the mouse lung. J Appl Physiol 2011;110:1455-1459.
    • Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, Armanios M. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med2011;184:904-912.
    • Pare PD, Mitzner W. Airway-parenchymal interdependence. Comprehensive Physiology2012;2:1921-1935.
    • Bishai JM, Mitzner W. Effect of severe calorie restriction on the lung in two strains of mice. American journal of physiology2008;295:L356-362.