Wayne Mitzner, PhD
Co-Director, Molecular Mechanisms and Pathophysiology
Baltimore , Maryland
410 614 5446
410 955 0299
Mitzner Lab: http://www.jhsph.edu/departments/environmental-health-sciences/mitzner/index.html
PhD Program: www.ephysiology.org
PhD , Johns Hopkins University , 1972
Brief description of current research activities:
My research interests are focused on the structural basis of physiologic lung function and how this normal structure manifests itself in pathologic situations and environmental exposures. Current work is concerned with understanding the mechanisms that underlie the chronic lung tissue destruction that occurs in emphysema. These functional and immunological studies in the mouse are directed toward investigating mechanisms of alveolar destruction with age or with emphysematous lesions. How this tissue destruction impacts the interaction between the lung parenchyma and airways plays a key role in the ability to breath in this pathology, and ongoing work is involved in studying this interaction. Additional funded work involves evaluating methods of impairing the ability of airway smooth muscle to shorten, as a possible treatment of asthma. The approach, termed bronchial thermoplasty, has direct clinical implications for the most severe asthmatic subjects. I also have a keen interest in understanding and developing methods to properly phenotype pulmonary function in the mouse, which is the most common experimental animal model of most human diseases. I’ve chaired several minisymposia and postgraduate courses in this area of mouse phenotyping.
Honors and Awards
Member of Tau Beta Pi, Eta Kappa Nu, & Sigma XI Honor Societies
1975 - 1978. Recipient of Young Investigator Pulmonary Research Grant
1978 - 1982. Recipient of NIH Research Career Development Award
1983 - 1993. Editorial Board of American Review of Respiratory Disease
1983 - present. Editorial Board of Journal of Applied Physiology
1996 Elected to the College of Fellows of the American Institute of Medical and Biological Engineering
2000. Distinguished Service Award from the American Lung Association of Maryland.
2006. Joseph Rodarte Award for Achievements in Respiratory Medicine and Physiology, awarded by the American Thoracic Society
2006 - 2008. Chair of Respiratory Structure & Function Assembly of the American Thoracic Society.
2007 - 2009. Chair of NIH study section on Respiratory integrative Biology and Translation
2010 - present. Consulting Editor, Journal of Applied Physiology
Research interests of Dr. Mitzner’s lab are focused on the structural basis of physiologic lung function and how this normal structure manifests itself in pathologic situations and environmental exposures. Current work is concerned with understanding the mechanisms that underlie the chronic lung tissue destruction that occurs in emphysema. These functional and immunological studies in the mouse are directed toward investigating mechanisms of alveolar destruction with age or with emphysematous lesions. How this tissue destruction impacts the interaction between the lung parenchyma and airways plays a key role in the ability to breath in this pathology, and ongoing work is involved in studying this interaction. Additional funded work involves evaluating method...
6. Brown RH, Kaczka DW, Fallano K, Shapiro S, and Mitzner W. Individual canine airway response variability to a deep inspiration. Clin Med Insights Circ Respir Pulm Med 5: 7-15, 2011.
7. Brown RH, Kaczka DW, and Mitzner W. Effect of parenchymal stiffness on canine airway size with lung inflation. PLoS One 5: e10332, 2010.
8. Chang HY, and Mitzner W. Sex differences in mouse models of asthma. Canadian journal of physiology and pharmacology 85: 1226-1235, 2007.
9. Chang HY, Mitzner W, and Watson J. Variation in airway responsiveness of male C57BL/6 mice from 5 vendors. Journal of the American Association for Laboratory Animal Science : JAALAS 51: 401-406, 2012.
10. Cheng RY, Shang Y, Limjunyawong N, Dao T, Das S, Rabold R, Sham JS, Mitzner W, and Tang WY. Alterations of the lung methylome in allergic airway hyper-responsiveness. Environmental and molecular mutagenesis 55: 244-255, 2014.
11. Craig JM, Scott AL, and Mitzner W. Elastase-coupled beads as a tool for characterizing localized alveolar tissue destruction associated with the onset of emphysema. J Appl Physiol 2013.
12. Das S, Macdonald K, Chang HY, and Mitzner W. A simple method of mouse lung intubation. Journal of visualized experiments : JoVE 2013.
13. Fallica J, Boyer L, Kim B, Serebreni L, Varela L, Hamdan O, Wang L, Simms T, Damarla M, Kolb TM, Bucala R, Mitzner W, Hassoun PM, and Damico R. Macrophage Migration Inhibitory Factor (MIF) is a Novel Determinant of Cigarette Smoke-induced Lung Damage. American journal of respiratory cell and molecular biology 2014.
14. Fallica J, Das S, Horton M, and Mitzner W. Application of carbon monoxide diffusing capacity in the mouse lung. J Appl Physiol 110: 1455-1459, 2011.
15. Jarrard J, Wizeman B, Brown RH, and Mitzner W. A theoretical model of the application of RF energy to the airway wall and its experimental validation. Biomed Eng Online 9: 81, 2010.
16. McGrath-Morrow SA, Lauer T, Collaco JM, Yee M, O'Reilly M, Mitzner W, Neptune E, Wise R, and Biswal S. Neonatal hyperoxia contributes additively to cigarette smoke-induced chronic obstructive pulmonary disease changes in adult mice. American journal of respiratory cell and molecular biology 45: 610-616, 2011.
17. Mitzner W. Emphysema--a disease of small airways or lung parenchyma? The New England journal of medicine 365: 1637-1639, 2011.
18. Mitzner W, and Smaldone G. Last word on viewpoint: unresolved mysteries. J Appl Physiol 113: 1950, 2012.
19. Podowski M, Calvi C, Metzger S, Misono K, Poonyagariyagorn H, Lopez-Mercado A, Ku T, Lauer T, McGrath-Morrow S, Berger A, Cheadle C, Tuder R, Dietz HC, Mitzner W, Wise R, and Neptune E. Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice. The Journal of clinical investigation 122: 229-240, 2012.
20. Reddy NM, Vegiraju S, Irving A, Paun BC, Luzina IG, Atamas SP, Biswal S, Ana NA, Mitzner W, and Reddy SP. Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation. The American journal of pathology 180: 562-574, 2012.
21. Shang Y, Das S, Rabold R, Sham JS, Mitzner W, and Tang WY. Epigenetic Alterations by DNA Methylation in House-Dust-Mite Induced Airway Hyperresponsiveness. American journal of respiratory cell and molecular biology 2013.
22. Smaldone GC, and Mitzner W. Viewpoint: unresolved mysteries. J Appl Physiol 113: 1945-1947, 2012.
23. Soutiere SE, and Mitzner W. On defining total lung capacity in the mouse. J Appl Physiol 96: 1658-1664, 2004.
24. Soutiere SE, Tankersley CG, and Mitzner W. Differences in alveolar size in inbred mouse strains. Respiratory physiology & neurobiology 140: 283-291, 2004.
25. Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT, Jr., Raman V, Zhen L, Mitzner WA, Sukumar S, and Semenza GL. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 31: 1757-1770, 2012.
1. Abston ED, Barin JG, Cihakova D, Bucek A, Coronado MJ, Brandt JE, Bedja D, Kim JB, Georgakopoulos D, Gabrielson KL, Mitzner W, and Fairweather D. IL-33 independently induces eosinophilic pericarditis and cardiac dilation: ST2 improves cardiac function. Circulation Heart failure 5: 366-375, 2012.
2. Abston ED, Coronado MJ, Bucek A, Onyimba JA, Brandt JE, Frisancho JA, Kim E, Bedja D, Sung YK, Radtke AJ, Gabrielson KL, Mitzner W, and Fairweather D. TLR3 deficiency induces chronic inflammatory cardiomyopathy in resistant mice following coxsackievirus B3 infection: role for IL-4. American journal of physiology Regulatory, integrative and comparative physiology 304: R267-277, 2013.
3. Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, and Armanios M. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med 184: 904-912, 2011.
4. Bennett BA, Mitzner W, and Tankersley CG. The effects of age and carbon black on airway resistance in mice. Inhalation toxicology 24: 931-938, 2012.
5. Bishai JM, and Mitzner W. Effect of severe calorie restriction on the lung in two strains of mice. American journal of physiology 295: L356-362, 2008.