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Wayne Mitzner, PhD

Director, Program in Respiratory Biology and Lung Disease

Professor

Departmental Affiliation(s):

Environmental Health Sciences

Contact Information

E-7608
Baltimore , Maryland
US        

410 614 5446
410 955 0299

SciVal Experts Research Profile

Education

PhD , Johns Hopkins University , 1972

Overview

Brief description of current research activities:

My research interests are focused on the structural basis of physiologic lung function and how this normal structure manifests itself in pathologic situations and environmental exposures.    His current work is concerned with understanding the mechanisms that underlie the chronic lung tissue destruction that occurs in emphysema.  These functional and immunological studies in the mouse are directed toward investigating mechanisms of alveolar destruction with age or with emphysematous lesions.  How this tissue destruction impacts the interaction between the lung parenchyma and airways plays a key role in the ability to breath in this pathology, and ongoing work is involved in studying this interaction.  Additional funded work involves evaluating methods of impairing the ability of airway smooth muscle to shorten, as a possible treatment of asthma.  The approach, termed bronchial thermoplasty, has direct clinical implications for the most severe asthmatic subjects.   I also have a keen interest in understanding and developing methods to properly phenotype pulmonary function in the mouse, which is the most common experimental animal model of most human diseases.  I’ve chaired several minisymposia and postgraduate courses in this area of mouse phenotyping.   

Honors and Awards

1963 - 67 Polytechnic Institute Unified Honors Program; Tau Beta Pi, Eta Kappa Nu, & Sigma XI Honor Societies

1975 - 78 Recipient of Young Investigator Pulmonary Research Grant

1978 - 82 Recipient of NIH Research Career Development Award (HL-00347)

1983 - 90 Editorial Board of American Review of Respiratory Disease

1983 - 96 Editorial Board of Journal of Applied Physiology 1996 ` Elected to the College of Fellows of the American Institute of Medical and Biological Engineering

1999-... Editorial Board of Journal of Applied Physiology 2000 Distinguished Service Award from the American Lung Association of Maryland.

2006 Joseph Rodarte Award for Achievements in Respiratory Medicine and Physiology

2006 - 08 Chair of Respiratory Structure & Function Assembly of the American Thoracic Society.

2007 -09  Chair of NIH study section on Respiratory integrative Biology and Translation

Environmental Health Sciences, asthma, emphysema, lung, airways, air pollution, angiogenesis, pathology, smooth muscle, pulmonary

  • Selected references (out of 276):

  • Mitzner W, Brown R, Lee W.  In vivo measurement of lung volumes in mice. Physiol Genomics.2001  Jan 19;4(3):215-21.

  • Ewart S, Levitt R, Mitzner W. Ventilation in mice with a solenoid-controlled airflow.  J Appl Physiol. 2001 May;90(5):2016-7.

  • Mitzner W, Brown R, Lee W.  In vivo measurement of lung volumes in mice. Physiol Genomics.2001 Jan 19;4(3):215-21.

  • Mitzner W.  Dynamic regulation of alveolar morphogenesis in mature lungs. Am J Physiol Lung Cell Mol Physiol. 2004 May;286(5):L893-5.