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Radamés J.B. Cordero, PhD

  • Research Associate

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Education

PhD, Albert Einstein College of Medicine, 2012
MS, Albert Einstein School of Medicine, 2008
BS, University of Puerto Rico - Arecibo, 2005

Overview

Dr. Cordero is a Research Associate in the laboratory of Dr. Arturo Casadevall. His research utilizes biophysical methods to study how melanization alters fungal biology and protects against environmental stressors associated with climate change (i.e. temperature, radiation, and humidity). By understanding the physicochemical properties of fungal melanins, Dr. Cordero hopes to learn about the ecology of fungi and animals and to exploit melanin’s unique properties for the development of new biotechnologies to improve human living, sustainability, and evolution.

In 2005, he graduated with a B.S. in Microbiology from the University of Puerto Rico, Arecibo (UPRA), and he received his M.S. with distinction in Biochemistry and his PhD. in Microbiology from Albert Einstein College of Medicine, NYC, in 2009 and 2012, respectively. His doctoral research work describes the structure, dynamics, and physicochemical properties of the Cryptococcus neoformans polysaccharide capsule; an important virulence factor required for causing disease in mammals. In 2013, after completing his Ph.D., Dr. Cordero received the Young Talent Attraction Scholarship to continue his research on biophysical microbiology at the Federal University of Rio de Janeiro, Brazil, where he studied virulence synergism between C. neoformans and Histoplasma capsulatum in a murine co-infection model. While in Brazil, he developed an interest in studying scholarly communication practices and bibliometry of the scientific literature. Dr. Cordero joined JHSPH in 2015.

  • fungal melanin
  • polysaccharide capsule
  • Cryptococcus neoformans
  • radioprotection
  • energy budgets
  • thermal biology
  • infrared imaging
  • color-mediated thermoregulation
  • thermography

Melanin is what makes human skin black, brown, reddish or yellowish, but this class of biological pigments are more than coloring agents. Found in all kingdoms of life, melanin provides photoprotection from dangerous solar radiation functioning both as a sunscreen and antioxidant by (1) absorbing and dissipating radiation energy in the form of heat, and (2) neutralizing free radicals caused by ionizing radiation. This radiation-to-heat conversion underlies their role in thermoregulation; it is essential for ‘cold-blooded’ organisms that rely on radiation, convection, and conduction to maintain healthy body temperatures. Recent studies with black fungi have shown that melanin can also convert high-energy electromagnetic radiation into chemical and electrical energy, resulting in enhanced fungal growth and metabolic activity; in a process analogous to photosynthesis. The ability of melanin to conduct electricity is perhaps one of the most exciting properties of these biopolymers, inspiring new applications in bioelectronics and other sustainable technologies. The structure of melanin remains largely unknown, yet its remarkable structural stability and strong affinity to water, metals, and other compounds make it resistant to a wide range of mechanical and chemical environmental stressors. The widespread presence of melanins in biology, unique properties, and diverse functions implies that the process of melanization possesses an ancient and conserved adaptation mechanism to changes in climate, making it significant for the evolution of life on Earth. Black fungi are notorious for inhabiting the most extreme environments on the planet such as Earth poles, desserts, hydrothermal vents, and radioactively polluted areas.