Kathleen C. Barnes, PhD
Director, Bayview Genetics Research Facility (BGRF) & The Lowe Family Genomics Core
School of Medicine (Primary)
Center & Institute Affiliation(s):
Dr. Barnes’ work focuses on the genetic basis for acute and chronic airway disease, and is based on diverse family-based and independent African Caribbean, South American, Western European (Netherlands, Germany), and local African American populations. Specifically, her studies are centered on gene-environment interactions and the interface of innate and adaptive immunity in the immunogenetics of various lung, allergic and infectious diseases including asthma, acute lung injury, atopic dermatitis and schistosomiasis.
She is currently leading a genomics project and a genomics Core for the Specialized Centers of Clinically-Oriented Research (SCCOR) on ‘Molecular Approaches to Ventilator-Associated Lung Injury’ (Roy Brower, PI), and leads the genetics/genomics Core sections in two additional SCCORS, one focusing on pulmonary hypertension and the other on various rheumatic diseases. Additionally, she leads a genetics projects on two different Center grants on asthma, an NIH contract on vaccinia in atopic dermatitis, in addition to her own and other NIH-funded studies. She was recently awarded the Genome-Wide Association Studies to Identify Genetic Components that Relate to Heart, Lung and Blood Disorders, RFA HL-06-012, to perform a study on Genome-Wide Association Studies of Asthma in Populations of African Descent (R01 HL087699-01, Barnes, PI).
Honors and Awards
1982 - VA Fellowship, Women's Business Association of Danville
1988 - Vining Davis Field Research Award to conduct post-graduate fieldwork in the Dominican Republic
1988 - S.C. Johnson Research Travel Award to conduct post-graduate fieldwork in the Dominican Republic
1991 - Dow-Elanco Research Travel Award to conduct post-graduate fieldwork in Barbados
1992 - University of Florida Graduate Student Council Travel Award, 37th Annual Meeting of the Commonwealth Caribbean Medical Research Council; Curaçao, Netherlands Antilles
1994 - American Academy of Allergy and Immunology Travel Award, 50th Annual Meeting of the American Academy of Allergy & Immunology; Anaheim, California 1994 - Boehringer Research Travel Award, 39th Annual Meeting of the Commonwealth Caribbean Medical Research Council; Kingston, Jamaica 1994 - Glaxo Research Travel Award, 39th Annual Meeting of the Commonwealth Caribbean Medical Research Council Kingston, Jamaica
1995 - American Academy of Allergy and Immunology Travel Award, 51st Annual Meeting of the American Academy of Allergy & Immunology; New York
1996 - Maryland Chapter Research Grant ($10,616.00), Asthma and Allergy Foundation of America
1998, 1999 - New Investigator Award Grant ($20,000.00), Asthma and Allergy Foundation of America 2004 - Assembly on Allergy Immunology & Inflammation Travel Award, 100th Annual Meeting of the American Thoracic Society
2005 - Resequencing & Genotyping Service Application Award ($447,438), National Heart, Lung and Blood Institute
2007 - Margaret Ellen Nielsen Endowed Fellowship in Medical Genetics ($100,000), Terry W. Taylor, MD & Julia Frey Taylor, BSN
Gao L, Flores C, Ma SF, Miller EJ, Moitra J, Moreno L, Wadgaonkar R, Simon B, McVerry B, Brower R, Sevransky J, Tuder RM, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Ye SQ, Barnes KC, Garcia JGN. Macrophage migration inhibitory factor in acute lung injury: Expression, biomarker and associations. Translational Research 2007, In press.
Williams MA, Cheadle C, Watkins T, Tailor A, Killedar S, Breysse P, Barnes KC, Georas SN. TLR2 and TLR4 as potential biomarkers of environmental particulate matter exposed human myeloid dendritic cells. Biomarker Insights 2007; 2: 225-39.
Howell MD, Kim BE, Gao P, Grant AV, Boguniewicz M, DeBenedetto A, Schneider L, Beck LA, Barnes KC, Leung DYM. Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol. 2007 (epub ahead of print).
Barnes KC, Grant AV, Hansel NN, Gao P, Dunston GM. African Americans with asthma. Proc. Am. Thoracic Soc. 2007; 4: 58-68.
Gao L, Grant AV, Rafaels N, Stockton-Porter M, Watkins T, Gao P, Chi P, Munoz M, Watson H, Dunston G, Togias A, Hansel N, Sevransky J, Maloney JP, Moss M, Shanholtz C, Brower R, Garcia JGN, Grigoryev DN, Cheadle C, Beaty TH, Mathias RA, Barnes KC. Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. J Allergy Clin Immunol. 2007; 119: 1111-8.