Daniela Cihakova, MD
- Assistant Professor
- Molecular Microbiology and Immunology (Joint)
- School of Medicine (Joint)
720 Rutland Avenue
Ross Building 648
Baltimore, Maryland 21205
PhD, Charles University, 2003
MD, Charles University, 1998
Daniela Cihakova, MD, PhD is an Assistant Professor in the Johns Hopkins Department of Pathology, Division of Immunology and a Director of the Immune Disorders Laboratory. Dr. Cihakova has a joint appointment in the Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health. She received her MD in 1998 and PhD in 2003 from Charles University, Prague, Czech Republic. Dr.Cihakova completed her postdoctoral fellowship with Noel Rose at Johns Hopkins University in 2006. She has been tenure track Assistant Professor since 2008. She received her ABMLI clinical laboratory immunologist certification in 2013. Dr. Cihakova is a member of the editorial board of Clinical Immunology and also serves on the American Heart Association Study Section. In her research, Dr.Cihakova focuses on gaining a better understanding the pathogenesis of autoimmune diseases. She examines the role of cardiac resident cells and monocytes/macrophages in the inflammatory heart disease and the development of dilated cardiomyopathy. With her collegues, she have described a new pathway that IL-17A, a key Th17 cytokine, utilizes to drive dilated cardiomyopathy, by stimulating cardiac fibroblast to produce GM-CSF and induce proinflammatory differentiation of monocytyes.
Dr.Cihakova's other interest are the pathogenic role of SSA/SSB antibodies in the development of congenital complete heart block and the susceptibility to Candida infections in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Her research has been supported by the Myocarditis Foundation, Children's Cardiomyopathy Foundation, W.W. Smith Charitable Trust, Mirowski Discovery Award, National Organization for Rare Diseases, and American Autoimmune Related Disease Association (AARDA) and NIH/NHBLI.
- Myocarditis, Dilated Cardiomyopathy
- Cardiac Fibroblasts
- macrophages, T cells
Most recent publications
Wu L, Ong S, Talor MV, Jobert G. Barin JG, Baldeviano GC, Kass DA, Bedja D, Zhang H, Sheikh A, Margolick JB, Iwakura5 Y, Rose NR, and Ciháková D*. Cardiac Fibroblasts Mediate IL-17A-Driven Inflammatory Dilated Cardiomyopathy. Journal of Experimental Medicine. 2014 211(7):1449-64
Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Fairweather D, Bedja D, Stickel NR, LeGault JA, Cardamone AB, Zheng D, Gabrielson KL, Rose NR, Ciháková D*. Fatal eosinophilic myocarditis develops in the absence of IFNγ and IL17A. J Immunol, 2013; 191(8):4038-47.
Barin JG and Ciháková D*. Control of inflammatory heart disease by CD4 (+) T cells. Ann N Y Acad Sci. 2013;1285(1):80-96.
Barin JG, Christian Baldeviano G, Talor MV, Wu L, Ong S, Quader F, Chen P, Zheng D, Caturegli P, Rose NR, Ciháková D*. Macrophages participate in IL-17-mediated inflammation. Eur J Immunol. 2011; 42(3):726-736
Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, Gabrielson K, Iwakura Y, Rose NR, Ciháková D*. Interleukin-17A Is Dispensable for Myocarditis but Essential for the Progression to Dilated Cardiomyopathy. Circ Res. 2010; 106(10):1646-1655