MD, University of Wisconsin, 1971
My primary research and teaching effort is directed toward the prevention of infectious diseases with the safest vaccines possible. I have conducted or participated in epidemiological studies of vaccine-preventable diseases and phase I, II, and III vaccine trials of hepatitis B, hepatitis A, inactivated polio virus, pertussis, Haemophilus influenzae type B, tetanus, Lyme disease, rotavirus, Argentina Hemorrhagic Fever, and influenzae vaccine viruses. The control of measles has been a particular focus of interest and I support the ongoing measles and poliomyelitis eradication efforts. My interest in vaccine safety stems from experience with vaccine-associated paralytic poliomyelitis, increased mortality after high-titer measles vaccines, and differences in response to acellular and wholecell pertussis vaccines. On-going studies include: persistent poliovirus excretion in immunodeficient children, evaluation of Lyme disease vaccine in children, evaluation of alternative injection devices, and the safety of preservatives and adjuvants in vaccines.