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Liang Zhao, PhD

  • Research Associate

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Center & Institute Affiliations

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615 N. Wolfe Street, Room W7032
Baltimore, Maryland 21205


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PhD, University of the Pacific, 2011


Dr. Liang Zhao received his Ph.D. degree in analytical chemistry from University of the Pacific (Stockton, CA, US). His research interests focus primarily on the applications of metabolomics in biological research. His current research includes applying both untargeted and targeted metabolomic approaches to explore the biological functions of metabolites. He is also interested in applying flux analysis by using stable isotope labeling approach to study metabolic pathways in human disease. He is familiar with different types of mass spectrometers and has extensive experience of applying these analytical tools in metabolomics and proteomics studies. He also obtained professional training in bioinformatics for metabolomics data processing and database development. His longer-term goals are focusing on the integration of mass spectrometry, biology and bioinformatics to address the biological importance of metabolites and proteins (including PTMs), and to better understand their roles in human disease and treatment options.

  • Metabolomics
  • Mass spectrometry
  • Metabolite profiling
  • Stable isotope-labeling
  • Metabolic flux analysis
  • Metabolic pathway analysis
  • Bioinformatics
  • Toxicology
  • Biomarker discovery

Selected Peer-reviewed Publications:

  • # A K Krug, S Gutbier, L Zhao, D Pöltl, C Kullmann, V Ivanova, S Förster, S Jagtap, J Meiser, G Leparc, S Schildknecht, M Adam, K Hiller, H Farhan, T Brunner, T Hartung, A Sachinidis and M Leist. Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP , Cell Death Dis. (2014) 5: e1223; doi:10.1038/cddis.2014.188 ************************************************************** # Liang Zhao, Thomas Hartung. Metabonomics and Toxicology, Metabonomics:Methods and Protocols (2015) (Book chapter, Springer) ******************************************************************************************* # A Elgogary, Q Xu, B Poore, J Alt, S Zimmermann, L Zhao, J Fu, ... B Slusher, A Le. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer, PNAS (2016): E5328-E5336. ************************************************************************************* # Erwin van Vliet, Elisenda Eixarch, Miriam Illa, Ariadna Arbat-Plana, Anna González-Tendero, Helena T Hogberg, Liang Zhao, Thomas Hartung, Eduard Gratacos. Metabolomics Reveals Metabolic Alterations by Intrauterine Growth Restriction in the Fetal Rabbit Brain. PLoS ONE, (2013) 8(5):e64545. doi:10.1371/journal.pone.0064545 **************************************************************************************** # Alexandra Maertens, Mounir Bouhifd, Liang Zhao, Shelly Odwin-DaCosta, Andre Kleensang, James D Yager, Thomas Hartung, Metabolomic network analysis of estrogen-stimulated MCF-7 cells: a comparison of overrepresentation analysis, quantitative enrichment analysis and pathway analysis versus metabolite network analysis. Archives of Toxicology,(2016), 1-14
  • # C E. Bowman, L Zhao, T Hartung, M J. Wolfgang. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series, Mol. Cell. Biol. (2016), doi:10.1128/MCB. 00166-16 ************************************************************************************************* # Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells. PNAS, (2015) 112(52):E7276-85 ************************************************************************************ # Mounir Bouhifd, Thomas Hartung, Helena T Hogberg, Andre Kleensang, Liang Zhao. Review: Toxicometabolomics. J. Appl. Toxicol. (2013) 12, 1365-1383
  • # Nina V Balmer, Tyna Dao, Marcel Leist, Kinga Vojnits, Tanja Waldmann, Liang Zhao, Helena T Hogberg, Erwin van Vliet. Application of “Omics” Technologies to In Vitro Toxicology, In Vitro Toxicology Systems, (2014) 399-432 (Book chapter) ******************************************************************************** # t4 Workshop Report: Pathways of Toxicty. ALTEX (2014) 31, 53-61 ********************************************** # Bouhifd, M., Beger, R., Flynn, T., Guo, L., ... Zhao, L., Hartung, T. Quality assurance of metabolomics. Altex, (2015), 32(4), 319-326. *********************************************************************************************** # Mounir Bouhifd, Helena T Hogberg, Andre Kleensang, Alexandra Maertens, Liang Zhao, Thomas Hartung. Mapping the Human Toxome by Systems Toxicology, Basic Clin. Pharmacol. Toxicol. (2014) DOI: 10.1111/bcpt.12198
  • # Thanh Pham, Tyler Chuang, Albert Lin, Hyun Joo, Jerry Tsai, Taylor Crawford, Liang Zhao, Yang Hsia, Caroline Williams, and Craig Anthony Vierra. Dragline Silk: A Fiber Assembled with Low-Molecular-Weight Cysteine-Rich Proteins. Biomacromolecules, (2014) Accepted, DOI: 10.1021/bm5011239 *********** # Yang Hsia, Eric Gnesa, Simon Tang, Felicia Jeffery, Paul Geurts, Liang Zhao, Andreas Franz, Craig Vierra. Identification and Synthesis of Novel Materials Based on Spider Fibers. Appl. Phys. A, (2011) 301-309 ************************************************************************************************************************* # Felicia Jeffery, Coby La Mattina, Tiffany Tuton-Blasingame, Yang Hsia, Eric Gnesa, Liang Zhao, Andreas Franz, and Craig Vierra. Microdissection of Black Widow Spider Silk-producing Glands. J Vis Exp. (2011) 47, doi: 10.3791/2382
  • # Paul Geurts, Liang Zhao, Yang Hsia, Eric Gnesa, Simon Tang, Felicia Jeffery, Coby La Mattina, Andreas Franz, Leah Larkin, Craig Vierra. Synthetic Spider Silk Fibers Spun from Pyriform Spidroin 2, A Glue Silk Protein Discovered in Orb-Weaving Spider Attachment Discs. Biomacromolecules, (2010) 12, 3495-503 ********************************************************************************************************************** # Eric Blasingame, Tiffany Tuton-Blasingame, Leah Larkin, Arnold M. Falick, Liang Zhao, Justine Fong, Veena Vaidyanathan, Anabelle Visperas, Paul Geurts, Xiaoyi Hu, Coby La Mattina, Craig Vierra. Pyriform Spidroin 1, a Novel Member of the Silk Gene Family That Anchors Dragline Silk Fibers in Attachment Discs of the Black Widow Spider, Latrodectus Hesperus. J. Biol. Chem. (2009) 284, 29097-108 ********** # Liang Zhao, Ruben T. Almaraz, Fan Xiang, Jerry L. Hedrickb, Andreas H. Franz. Gas-Phase Scrambling of Disulfide Bonds during Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. J. Am. Soc. Mass. Spectr. (2009) 20, 1603-16