Corinne E. Joshu, PhD
- Assistant Professor
- Division: Cancer Epidemiology
Center & Institute Affiliations
- George W. Comstock Center for Public Health Research and Prevention
- Welch Center for Prevention, Epidemiology and Clinical Research
615 N. Wolfe Street
Baltimore, Maryland 21205
PhD, Saint Louis University, 2008
MPH, Saint Louis University, 2007
MA, Boston University, 2002
Dr. Joshu's research focuses on the prevention of colorectal and prostate cancers, including (1) the role of modifiable factors, in particular obesity, on the risk of colorectal and prostate cancer outcomes, and (2) the early detection of these cancers through both established and new modalities. The purpose of her work is to develop prevention strategies, and to translate population-based research into clinically useful tools.
Her work on colorectal cancer explores the association of obesity and diabetes and their metabolic consequences with colorectal cancer and precursor lesions, and informs the prioritization of intervention efforts based on the national prevalences of modifiable risk factors. She also seeks to improve colorectal cancer screening via (1) identifying over or under screened groups, (2) identifying opportunities for quality improvement and quality assurance, and (3) exploring new modalities for screening (e.g. KRAS mutations in circulating blood).
Her work on poor prostate cancer outcomes focuses on identifying biological mechanisms by which modifiable factors may influence recurrence, including studies on prostate tissue-based measures of inflammation, hormones, growth factors, and oxidation. She also seeks to reduce poor prostate cancer outcomes by investigating whether modification of risk factors for chronic disease incidence reduces risk of recurrence after treatment and improving prostate cancer prognostication via the optimization and validation of an independent prognostic tissue biomarker (e.g. telomere length).
Honors and Awards
Delta Omega Honorary Public Health Society, Alpha Delta Chapter
Martin D. Abeloff, MD Scholar-in-Training in Cancer Prevention and Control, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Epidemiology, prevention, prostate cancer, colorectal cancer, adenomatous polyps, lifestyle, race, telomeres, inflammation, obesity, screening
Joshu CE, Peskoe SB, Heaphy CM, Kenfield SA, Van Blarigan EL, Mucci LA, Giovannucci E, Stampfer MJ, Yun GS, Lee T, Hicks JL, De Marzo AM, Meeker AK, Platz EA. Pre-diagnostic obesity and inactivity are associated with shorter telomere length in prostate stromal cells. Cancer Prev Res. 2015. Cancer Prev Res. 8(8):737-42 PMC4526348
Han X, Stevens J, Truesdale KP, Bradshaw PT, Kucharska-Newton A, Prizment AE, Platz EA, Joshu CE. Body mass index at early adulthood, subsequent weight change, and cancer incidence and mortality. 2014. International Journal of Cancer. 135(12):2900-9. PMC4192093
Joshu CE, Prizment AE, Dluzniewski DJ, Menke A, Folsom AR, Coresh J, Yeh HC, Brancati FL, Platz EA, Selvin E. Glycated Hemoglobin and Cancer Incidence and Mortality in the Atherosclerosis in Communities (ARIC) Study, 1990-2006. 2011. International Journal of Cancer. 131(7):1667-77. PMC3906204
Joshu CE, Parmigiani G, Colditz GA, Platz EA. Opportunities for the primary prevention of colorectal cancer in the United States. 2012. Cancer Prev Res. 5(1):138-45. PMC3252472
- ARIC Cancer