Marcelo Jacobs-Lorena, PhD
- Molecular Microbiology and Immunology (Primary)
Center & Institute Affiliations
615 N. Wolfe Street
Baltimore, Maryland 21205
Personal website: http://jhmmi.jhsph.edu/Faculty/jacobs_lorena/FrameForm.cfm
PhD, Massachusetts Institute of Technology, 1972
MSc, Osaka University, 1967
Mosquitoes as Vectors for the Malaria Parasite
Our research covers four topics:
o Genetic modification of mosquito vectorial capacity o Mosquito-Plasmodium interactions o Gene expression during Plasmodium development in the mosquito o Structure and function of the peritrophic matrix (PM)
- malaria mosquitoes transgenesis Plasmodium-mosquito interacions peritrophic matrix
Srinivasan P, Coppens I and Jacobs-Lorena M (2008) Distinct roles of Plasmodium Rhomboid 1 in parasite development and malaria pathogenesis. PLoS Pathogens 5(1) e1000262.
Ghosh AK, Devenport M, Jethwaney D, Kalume DE, Pandey A, Anderson VE, Sultan AA, Kumar N and Jacobs-Lorena M (2008) Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins. PLoS Pathogens, 5(1)e1000265.
Dinglasan RR, Devenport M, Florens L, Johnson JR, McHugh CA, Donnelly-Doman, M, Carucci DJ, Yates JR. III and Jacobs-Lorena, M (2008) The Anopheles gambiae adult midgut peritrophic matrix proteome. Insect Biochem. Mol. Biol, in press.
Srinivasan P, Fujioka H and Jacobs-Lorena M (2008) PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito. Cell. Microbiol. 10:1304-1312.
Li C, Marrelli MT, Yan G and Jacobs-Lorena M (2008) Fitness of transgenic Anopheles stephensi mosquitoes expressing the SM1 peptide under the control of a vitellogenin promoter. J. Hered. 99:275-282.