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Thomas Sussan, PhD

  • Assistant Scientist

Departmental Affiliations

Contact Information

615 N. Wolfe Street, Room E7035
Baltimore, Maryland 21205

410-502-1949
410-955-0116

SciVal Research Profile

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Education

PhD, Johns Hopkins School of Medicine, 2006

Overview

I am interested in how various environmental exposures (ie. cigarette smoke, electronic cigarette vapor, indoor/outdoor air pollution, allergens, bacteria, and viruses) result in respiratory respiratory diseases, such as COPD, asthma, and innate immune dysfunction. We are interested in identifying biochemical pathways that alter susceptibility to disease, through genetically modified animal models and pharmacological agents. 

Honors and Awards

2015                Preparing Future Faculty Teaching Academy Summer Institute, Johns Hopkins University

2014                Summer Institute in Environmental Health Sciences, Johns Hopkins School of Public Health

2012                Household Air Pollution Training Institute participant, National Center for Global Health Studies at the NIH Fogarty International Center.

2011                Chairperson- “Epigenetics in Toxicology: Introduction, Mechanistic Understanding, and Applications in Safety Assessment.” Society of Toxicology, Continuing Education Course. Washington, DC.

2010-               Director, Johns Hopkins Lung Diseases Preclinical Animal Model Core Facility

2010-               Flight Attendants Medical Research Institute (FAMRI) Young Clinical Scientist Award

2006-2009       National Institute of Environmental Health Sciences Training Award [T32]

2005                Teaching Assistant in “Mammalian Genetics”, in graduate course Fundamentals of Genetics, Johns Hopkins School of Medicine, Baltimore, MD

2003                Summer Institute in Statistical Genetics, North Carolina State University, Raleigh, NC

2001                Travel Award for the short course on “Experimental Genetics of the Laboratory Mouse in Cancer Research”, Jackson Laboratory, Bar Harbor, ME

1998-2000       Faculty Research Assistant, Department of Cellular Biology and Molecular Genetics, University of Maryland, College Park, MD

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  • Cigarette smoke, biomass, household air pollution, oxidative stress, inflammation,asthma
  • Sussan TE, Gajghate S, Thimmulappa RK, Ma J, Kim JH, Sudini K, Consolini N, Cormier SA, Lomnicki S, Hasan F, Pekosz A, and Biswal S. (2015) Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLOS ONE. 10, e0116861.

  • Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S. (2009). Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A 106(1):250-5

  • Sussan TE, Ingole V, Kim J, McCormick S, Negherbon J, Fallica J, Akulian J, Yarmus L, Feller-Kopman D, Wills-Karp, M, Horton, MR, Breysse, PN, Agrawal, A, Juvekar, S, Salvi, S, Biswal, S. Source of biomass cooking fuel determines pulmonary response to household air pollution. (2014) Am J Respir Cell Mol Biol. 2014 Mar;50(3):538-48.

  • Sussan TE, Gajghate S, Chatterjee S, Mandke P, McCormick S, Sudini K, Kumar S, Breysse PN, Diette GB, Sidhaye VK, Biswal S. (2015) Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function. Am J Physiol Lung Cell Mol Physiol. 2015 May 8:ajplung.00398.2014. doi: 10.1152/ajplung.00398.2014

  • Sussan, TE, Yang, A, Li, F, Ostrowski, M, and Reeves, RH. (2008). Trisomy represses ApcMin-mediated tumors in mouse models of Down syndrome. Nature 451(7174):73-5.