Lawrence J. Appel, MD
Center & Institute Affiliation(s):
Welch Center for Prevention
2024 E. Monument Street, Room 2-600
Baltimore , Maryland 21287
MD , New York University School of Medicine , 1981
MPH , Johns Hopkins Bloomberg School of Public Health , 1989
I am currently Director of the Welch Center for Prevention, Epidemiology and Clinical Research, a large interdisciplinary research unit that bridges the Schools of Medicine and Public Health at Hopkins. The mission of the Welch Center is to conduct epidemiologic, clinical and translational research of the highest quality and to train the next generation of interdisciplinary researchers.
As for my own research, I have conducted clinical research with a particular focus on preventing blood pressure-related cardiovascular and kidney diseases. I have three active lines of research: (1) controlled feeding studies, (2) behavioral intervention trials, that test novel strategies to accomplish lifestyle changes, often related to obesity, and (3) cohort studies and trials related to chronic kidney disease and its consequences. A particularly notable feature of my research is the focus on conditions and diseases that disproportionately afflict minorities and on interventions that have the potential to substantially reduce racial disparities.
Over the course of my carerr, I have mentored numerous students, fellows and faculty (and continue to do so). This aspect of my career is incredibly enjoyable and rewarding.
Honors and Awards
2010 Director, Welch Center for Prevention, Epidemiology and Clinical Research
2010 Conner Award Lecturer, American Heart Association
2008 David M. Levine Excellence in Mentoring Award
2007 Distinguished Lecturer, University of Mississippi School of Medicine
2006 Epidemiologic Inquiry Accolade: Randomized Trial of the Month (OmniHeart)
2006 Distinguished Researcher, the International Society of Hypertension in Blacks (ISHIB)
2005 Top 4th Percentile in NIH Funding, 1977-2002
Cardiovascular disease, kidney disease, hypertension, diet, lifestyle modifications, clincal trials
Appel LJ, Wright JT, Greene T, et al. Intensive blood-pressure control in hypertensive chronic kidney disease. N Engl J Med 2010:363(10):918-929. PMID: 20818902
Lloyd-Jones D, Hong Y, Labarthe D, Mozaffarian, D, Appel L, et al. Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction: The American Heart Association’s Strategic Impact Goal Through 2020 and Beyond. Circulation. 2010;121:586-613. PMID: 20089546
Appel LJ, Anderson CA. Compelling Evidence for Public Health Action to Reduce Salt Intake, NEJM 2010; 362:651-2. PMID: 20089959
Yeung EH, Appel LJ, Miller ER 3rd, Kao WH. The Effects of Macronutrient Intake on Total and High-molecular Weight Adiponectin: Results From the OMNI-Heart Trial. Obesity (Silver Spring). 2009 Oct 29. [Epub ahead of print] PMID: 19876001