Sabra L. Klein, PhD
- Associate Professor
Center & Institute Affiliations
615 N. Wolfe Street
Baltimore, Maryland 21205
PhD, Johns Hopkins University, 1998
MA, University of Georgia, 1996
MS, University of Georgia, 1994
BA, Randolph-Macon College, 1992
The overarching goal of my research program is to uncover the mechanisms mediating how males and females differ in their immune responses to viral infection and vaccination. We hypothesize that sex steroids and signaling through sex steroid receptors are critical pathways modulating immune responses to viruses. We consider how immunological, hormonal, and genetic differences between males and females affect sex differences in susceptibility to viruses, including influenza viruses. Our research indicates that females typically mount more robust immune responses than males, which can be beneficial for clearance of viruses, but also can be detrimental by causing immunopathology.
Honors and Awards
2010 Society for Women’s Health Research Medtronic Award for Science Contributions
2007 Johns Hopkins Bloomberg School of Public Health Faculty Innovation Fund Award
2002 National Foundation for Infectious Diseases New Investigator Award
- Molecular Microbiology and Immunology, Endocrine Disruption, Endocrine-Immune Interactions,
- Hormones, Neuroendocrinology, Immunology, Infectious Diseases, Influenza, Phytoestrogens, Pregnancy, Reproduction, Sex Differences, Vaccines, Viruses, Women's Health
Klein, S. L., Schiebinger, L., Stefanick, M. L., Cahill, L., Danska, J. S., de Vries, G. J., Kibbe, M. R., McCarthy, M. M., Mogil, J. S., Woodruff, T. K., & Zucker, I. 2015. Sex inclusion in basic research drives discovery. Proceedings of the National Academy of Sciences USA, 112(17):5257-8.
Robinson, D. P., Hall, O. A., Nilles, T. L., Bream, J. H., & Klein. S. L. 2014. 17-estradiol protects females against influenza by recruiting neutrophils and increasing virus-specific CD8 T cell responses in the lungs. Journal of Virology, 88, 4711-20.
Lorenzo, M., Hodgson, A., Kaplan, J., Robinson, D. P., Pekosz, A., & Klein, S. L. 2011. Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice. Vaccine 29:9246-9255.
Robinson, D. P., Lorenzo, M., Jian, W., & Klein, S. L. 2011. Elevated 17β-estradiol protects females from influenza A virus pathogenesis by suppressing inflammatory responses. PLoS Pathogens, 7(7): e1002149. Doi:10.1371/journal.ppat.1002149
Klein, S. L., Jedlicka, A. E., & Pekosz, A. 2010. The Xs and Y of immune responses to viral vaccines. Lancet Infectious Diseases, 10, 338-49.
- CENTER OF EXCELLENCE FOR INFLUENZA RESEARCH AND SURVEILLANCE (CEIRS)