The mission of the training program is to actively prepare research scientists to become future leaders of individual and interdisciplinary research projects that seek to understand the role environmental exposures play in the etiology and exacerbation of human disease at the individual and population level. The program provides support for predoctoral and postdoctoral trainees involved in research on the role of exposures to environmental agents (e.g., various chemicals, metals, particulates, fungal- or bacterial-derived toxicants) as causative agents or co-factors in human disease. Trainee research will focus on one or more of the following: - Mechanisms of exposures to environmental agents that alter biological processes that contribute to disease pathobiology
- Development of biomarkers of disease pathobiology (e.g., biomarkers of response, effect and susceptibility to toxic agents)
- Development of intervention strategies based upon mechanistic studies to prevent adverse effects that contribute to disease caused by exposure to environmental agents
- Epidemiology to identify population-based associations of environmental agents with disease
Research of the training faculty is focused on the role of environmental agents in the following diseases: - Cancer
- Immune System Diseases
- Neurological Diseases
- Pulmonary and Cardiovascular Diseases
- Reproductive and Developmental Diseases
Faculty and trainee research address one or more of the following areas: - Mechanisms of disease pathobiology
- Development of biomarkers of the pathobiology (e.g., biomarkers of response, effect, susceptibility)
- Development of prevention intervention strategies
- Disease epidemiology
As of May 2007, this NIEHS Training Program (ES07141) had supported 62 predoctoral and 24 postdoctoral trainees since 1996. Forty-three predoctoral and 20 postdoctoral trainees now hold career positions in the private sector/industry, government or academia. Current and former trainees have published over 300 peer-reviewed papers and book chapters.
Center Director: John Groopman, PhD
Faculty | Department * | Rank | Research Interests | | | Baylin, Stephen | EHS/TOX ** | Professor | Epigenetics; DNA methylation; histone de-acetylase; histone methylating enzyme; transcriptional silencing | | Casero, Robert | EHS/TOX ** | Professor | Polyamines; spermine oxidase (SMO); H2O2; environmental agents (asbestos and other airborne irritants); lung damage and inflammation, DNA damage | | Groopman, John | EHS/TOX | Professor | Molecular epidemiology of chemical carcinogen exposures; cancer prevention and control | | Strickland, Paul | EHS/OEH | Professor | Environmental and occupational carcinogenesis; biomarkers of exposure and risk; molecular epidemiology | | Visvanathan, Kala | EPI | Assistant Professor | Development and validation of biomarkers of breast cancer; clinical interventions in women at risk for breast cancer | | Yager, James | EHS/TOX | Professor | Mechanisms of estrogen carcinogenesis in breast cancer; genetic susceptibility to breast cancer; estrogen oxidative metabolites; environmental estrogens; estrogen receptor signaling pathways | | | Schwab, Kellogg | EHS/EHE | Associate Professor | Environmental exposure to microbial and chemical agents, nanomaterials, antibiotic resistance, intervention strategies | | Silbergeld, Ellen | EHS/EHE | Professor | Interactions of lead and mercury with immune system; antibiotic resistance in poultry production workers | | Trush, Michael | EHS/TOX | Professor | Reactive oxygen mitochondria; signal transduction; benzene, benzo(a)pyrene; leukocytes, polymorphonuclear leukocytes; macrophages; bone marrow progenitors; aplastic anemia; agranulocytosis; leukemia | | | Bressler, Joe | EHS/TOX | Associate Professor | Lead, zinc, iron; neurodevelopment; transporters | | Culotta, Valeria | BMB/EHS | Professor | Transition metals and oxygen-free radicals; molecular genetics of the oxidative stress response | | Schwartz, Brian | EHS/OEH | Professor | Environmental causes of cognitive decline; biomarkers of exposure, health risk, and susceptibility; gene-environment interaction, particularly for lead exposure | | | Biswal, Shyam | EHS/TOX | Associate Professor | Nrf2, antioxidants; oxidative stress; nitrosative stress; COPD, asthma; innate immune response | | Breysse, Patrick | EHS/EHE | Professor | Environmental exposure assessment and biomarkers | | Fairweather, Delisa | EHS/TOX | Assistant Professor | Infection as a co-factor with metals; particulates or bacterial-derived toxins on cardiovascular disease; autoimmunity; sex differences | | Gabrielson, Kathy | COMP MED | Assistant Professor | Cigarette smoke; air pollution; heart disease; inflammation; hypertension; hypertrophy; atherosclerosis; metal toxicity | | Navas-Acien, Ana | EHS/OEH | Assistant Professor | Environmental epidemiology; cardiovascular epidemiology; epidemiologic methods; systematic reviews and meta-analysis; biomarkers; arsenic; heavy metals; secondhand smoke | | Tankersley, Clarke | EHS/PHYS | Associate Professor | Environmental stress physiology; mouse genetics; pulmonary physiology; linkage analysis; control of ventilation; genetic susceptibility; air pollutant toxicology | | Weaver, Virginia | EHS/OEH | Associate Professor | Molecular epidemiology involving biomarkers for metals exposure and renal outcomes; occupational and environmental nephrotoxicants, particularly lead, cadmium and mercury; gene-environment interaction | | | Brown, Terry | BMB/Repro Biol | Professor | Androgen; prostate; benign prostatic hyperplasia; testis; spermatogenesis | | Evans, Janice | BMB/Repro Biol | Associate Professor | Mechanisms of sperm-egg membrane-binding and fusion; oocyte maturation | | Zirkin, Barry | BMB/Repro Biol | Professor | Leydig cells; reactive oxygen species (ROS); ROS scavenging molecules; stem Leydig cells; environmental antiandrogens; fetal basis of adult disease | | Drummond-Barbosa, Daniela | BMB/Repro Biol | Assistant Professor | Mechanisms of stem cell responses to environmental agents in the Drosophila model system; germline stem cells; oogenesis; genetics; endocrinology; physiology. |
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