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Department of Environmental Health Sciences

NIEHS Training Program in Environmental Health Sciences

The mission of the training program is to actively prepare research scientists to become future leaders of individual and interdisciplinary research projects that seek to understand the role environmental exposures play in the etiology and exacerbation of human disease at the individual and population level. The program provides support for predoctoral and postdoctoral trainees involved in research on the role of exposures to environmental agents (e.g., various chemicals, metals, particulates, fungal- or bacterial-derived toxicants) as causative agents or co-factors in human disease.

Trainee research will focus on one or more of the following:

  • Mechanisms of exposures to environmental agents that alter biological processes that contribute to disease pathobiology
  • Development of biomarkers of disease pathobiology (e.g., biomarkers of response, effect and susceptibility to toxic agents)
  • Development of intervention strategies based upon mechanistic studies to prevent adverse effects that contribute to disease caused by exposure to environmental agents
  • Epidemiology to identify population-based associations of environmental agents with disease

Research of the training faculty is focused on the role of environmental agents in the following diseases:

  • Cancer
  • Immune System Diseases
  • Neurological Diseases
  • Pulmonary and Cardiovascular Diseases
  • Reproductive and Developmental Diseases

Faculty and trainee research address one or more of the following areas:

  • Mechanisms of disease pathobiology
  • Development of biomarkers of the pathobiology (e.g., biomarkers of response, effect, susceptibility)
  • Development of prevention intervention strategies
  • Disease epidemiology

As of May 2007, this NIEHS Training Program (ES07141) had supported 62 predoctoral and 24 postdoctoral trainees since 1996. Forty-three predoctoral and 20 postdoctoral trainees now hold career positions in the private sector/industry, government or academia. Current and former trainees have published over 300 peer-reviewed papers and book chapters.


training program contact information

Center Director: John Groopman, PhD

TRAINING FACULTY

Faculty

Department *  

Rank

Research Interests

CANCER

Baylin, StephenEHS/TOX **Professor

Epigenetics; DNA methylation; histone de-acetylase; histone methylating enzyme; transcriptional silencing

Casero, RobertEHS/TOX **Professor

Polyamines; spermine oxidase (SMO); H2O2; environmental agents (asbestos and other airborne irritants); lung damage and inflammation, DNA damage

Groopman, JohnEHS/TOXProfessor

Molecular epidemiology of chemical carcinogen exposures; cancer prevention and control

Strickland, PaulEHS/OEHProfessor

Environmental and occupational carcinogenesis; biomarkers of exposure and risk; molecular epidemiology

Visvanathan, KalaEPIAssistant
Professor

Development and validation of biomarkers of breast cancer; clinical interventions in women at risk for breast cancer

Yager, JamesEHS/TOXProfessor

Mechanisms of estrogen carcinogenesis in breast cancer; genetic susceptibility to breast cancer; estrogen oxidative metabolites; environmental estrogens; estrogen receptor signaling pathways

Immune System Disease

Schwab, KelloggEHS/EHEAssociate Professor

Environmental exposure to microbial and chemical agents,                       nanomaterials, antibiotic resistance, intervention strategies

Silbergeld, EllenEHS/EHEProfessorInteractions of lead and mercury with immune system; antibiotic resistance in poultry production workers
Trush, MichaelEHS/TOXProfessorReactive oxygen mitochondria; signal transduction; benzene, benzo(a)pyrene; leukocytes, polymorphonuclear leukocytes; macrophages; bone marrow progenitors; aplastic anemia; agranulocytosis; leukemia
Neurological Disease
Bressler, JoeEHS/TOXAssociate
Professor
Lead, zinc, iron; neurodevelopment; transporters
Culotta, ValeriaBMB/EHSProfessorTransition metals and oxygen-free radicals; molecular genetics of the oxidative stress response
Schwartz, BrianEHS/OEHProfessorEnvironmental causes of cognitive decline; biomarkers of exposure, health risk, and susceptibility; gene-environment interaction, particularly for lead exposure
Pulmonary and Cardiovascular Disease
Biswal, ShyamEHS/TOXAssociate
Professor
Nrf2, antioxidants; oxidative stress; nitrosative stress; COPD, asthma; innate immune response
Breysse, PatrickEHS/EHEProfessorEnvironmental exposure assessment and biomarkers
Fairweather, DelisaEHS/TOXAssistant
Professor
Infection as a co-factor with metals; particulates or bacterial-derived toxins on cardiovascular disease; autoimmunity; sex differences
Gabrielson, KathyCOMP MEDAssistant
Professor
Cigarette smoke; air pollution; heart disease; inflammation; hypertension; hypertrophy; atherosclerosis; metal toxicity
Navas-Acien, AnaEHS/OEHAssistant
Professor
Environmental epidemiology; cardiovascular epidemiology; epidemiologic methods; systematic reviews and meta-analysis; biomarkers; arsenic; heavy metals; secondhand smoke
Tankersley, ClarkeEHS/PHYSAssociate ProfessorEnvironmental stress physiology; mouse genetics; pulmonary physiology; linkage analysis; control of ventilation; genetic susceptibility; air pollutant toxicology
Weaver, VirginiaEHS/OEHAssociate ProfessorMolecular epidemiology involving biomarkers for metals exposure and renal outcomes; occupational and environmental nephrotoxicants, particularly lead, cadmium and mercury; gene-environment interaction
Reproductive and Developmental Disease
Brown, TerryBMB/Repro BiolProfessorAndrogen; prostate; benign prostatic hyperplasia; testis; spermatogenesis
Evans, JaniceBMB/Repro BiolAssociate ProfessorMechanisms of sperm-egg membrane-binding and fusion; oocyte maturation
Zirkin, BarryBMB/Repro BiolProfessorLeydig cells; reactive oxygen species (ROS); ROS scavenging molecules; stem Leydig cells; environmental antiandrogens; fetal basis of adult disease
Drummond-Barbosa, DanielaBMB/Repro BiolAssistant Professor

Mechanisms of stem cell responses to environmental agents in the Drosophila model system; germline stem cells;  oogenesis; genetics; endocrinology;  physiology.

* The departments of Environmental Health Sciences (EHS), Biochemistry and Molecular Biology (BMB) and Epidemiology (EPI) are in the School of Public Health. EHS is an interdisciplinary department with four divisions/program areas: Environmental Health Engineering (EHE), Occupational & Environmental Health (OEH), Physiology (PHYS), and Molecular and Translational Toxicology (TOX).

** Drs. Baylin and Casero have primary appointments in the Departments of Oncology and Comparative Medicine in the School of Medicine, and joint appointments in EHS/TOX.

EHS Training Programs

NIEHS Training Program in Environmental Health Sciences

Multidisciplinary Training Program in Lung Diseases

Occupational and Environmental Medicine Residency Program

Connecting Students to Environmental  Health Researchers  

Environmental Health Sciences

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