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The mission of the training program is to actively prepare research scientists to become future leaders of individual and interdisciplinary research projects that seek to understand the role environmental exposures play in the etiology and exacerbation of human disease at the individual and population level. The mission will be accomplished by providing support for pre- and postdoctoral trainees involved in research on the role of exposures to environmental agents (e.g. various chemicals, metals, particulates, fungal or bacterial-derived toxicants) as causative agents or co-factors in human disease. Trainee research will focus on one or more of the following: - Mechanisms of exposures to environmental agents that alter biological processes that contribute to disease pathobiology
- Development of biomarkers of disease pathobiology (e.g. biomarkers of response, effect, and susceptibility to toxic agents)
- Development of intervention strategies based upon mechanistic studies to prevent adverse effects that contribute to disease caused by exposure to environmental agents
- Epidemiology to identify population-based associations of environmental agents with disease
Research of the training faculty is focused on investigations on the contributions of environmental agents to the following diseases: The research being conducted by the faculty together with predoctoral and postdoctoral trainees addresses one or more of the following: - Mechanisms of disease pathobiology
- Development of biomarkers of the pathobiology (e.g. biomarkers of response, effect, susceptibility)
- Development of prevention intervention strategies
- Disease epidemiology
As of May 2007, this NIEHS Training Program (ES07141) had supported 62 former predoctoral and 24 former postdoctoral trainees since 1996. Forty-three former predoctoral and 20 former postdoctoral trainees are in career positions in the private sector/industry, government or academia. Combined, current and former trainees have published over 300 peer-reviewed papers and book chapters.
Individuals interested in training in these areas and becoming a trainee supported by this training program must first be accepted into a doctoral program in either the departments of Biochemistry and Molecular Biology, Epidemiology or Environmental Health Sciences and plan to, or be working under, the mentorship of a member of the training faculty listed below. Such individuals may then be nominated for a predoctoral or postdoctoral position in this training program by their mentor. Applications to the doctoral and postdoctoral programs in these departments can be found at www.jhsph.edu/resources/prospective_students/ and clicking on Admissions. For more information on this training program, contact Kay Castleberry at kcastleb@jhsph.edu.
Faculty | Department * | Rank | Research Interests | CANCER | | Baylin, Steve | EHS/TOX ** | Professor | Epigenetics; DNA methylation; histone de-acetylase; histone methylating enzyme; transcriptional silencing | | Casero, Robert | EHS/TOX ** | Professor | Polyamines; spermine oxidase (SMO); H2O2; environmental agents (asbestos and other airborne irritants); lung damage and inflammation, DNA damage | | Groopman, John | EHS/TOX | Professor | Molecular epidemiology of chemical carcinogen exposures; cancer prevention and control | | Halden, Rolf | EHS/EHE | Assistant Professor | Bioavailability, metabolism, and environmental detection of water- and airborne microcontaminants | | Kensler, Thomas | EHS/TOX | Professor | Molecular mechanisms of chemical carcinogenesis; reactive oxygen; cancer chemoprevention | | Strickland, Paul | EHS/OEH | Professor | Environmental and occupational carcinogenesis; biomarkers of exposure and risk; molecular epidemiology | | Visvanathan, Kala | EPI | Assistant Professor | Development and validation of biomarkers of breast cancer; clinical interventions in women at risk for breast cancer | | Watson, Walter | EHS/TOX | Assistant Professor | Thioredoxin; redox signaling; thiols; reactive oxygen species; arsenic | | Yager, James | EHS/TOX | Professor | Mechanisms of estrogen carcinogenesis in breast cancer; genetic susceptibility to breast cancer; estrogen oxidative metabolites; environmental estrogens; estrogen receptor signaling pathways | Immune System Disease | | Silbergeld, Ellen | EHS/EHE | Professor | Interactions of lead and mercury with immune system; antibiotic resistance in poultry production workers | | Trush, Michael | EHS/TOX | Professor | Reactive oxygen mitochondria; signal transduction; benzene, benzo(a)pyrene; leukocytes, polymorphonuclear leukocytes; macrophages; bone marrow progenitors; aplastic anemia; agranulocytosis; leukemia | | Neurological Disease | | Bressler, Joe | EHS/TOX | Associate Professor | Lead, zinc, iron; neurodevelopment; transporters | | Culotta, Valeria | EHS/TOX | Professor | Transition metals and oxygen free radicals; molecular genetics of the oxidative stress response | | Guilarte, Tomas | EHS/TOX | Professor | Neurotoxicology of lead; NMDA receptors and signal transduction; biomarkers of neurotoxicity | | Schwartz, Brian | EHS/OEH | Professor | Environmental causes of cognitive decline; biomarkers of exposure, health risk, and susceptibility; gene-environment interaction, particularly for lead exposure | | Pulmonary and Cardiovascular Disease | | Biswal, Shyam | EHS/TOX | Associate Professor | Nrf2, antioxidants; oxidative stress; nitrosative stress; COPD, asthma; innate immune response | | Breysse, Patrick | EHS/EHE | Professor | Environmental exposure assessment and biomarkers | | Fairweather, Delisa | EHS/TOX | Assistant Professor | Infection as a co-factor with metals; particulates or bacterial-derived toxins on cardiovascular disease; autoimmunity; sex differences | | Gabrielson, Kathy | COMP MED | Assistant Professor | Cigarette smoke; air pollution; heart disease; inflammation; hypertension; hypertrophy; atherosclerosis; metal toxicity | | Navas-Acien, Ana | EHS/OEH | Assistant Professor | Environmental epidemiology; cardiovascular epidemiology; epidemiologic methods; systematic reviews and meta-analysis; biomarkers; arsenic; heavy metals; secondhand smoke | | Reddy, Sekhara | EHS/PHYS | Associate Professor | Environmental pollutants; lung injury and repair; bronchial carcinogenesis; cigarette smoke; oxidants and antioxidants; hyperoxia, gene regulation; transcription factors; AP-1, Nrf2; signal transduction | | Tankersley, Clarke | EHS/PHYS | Associate Professor | Environmental stress physiology; mouse genetics; pulmonary physiology; linkage analysis; control of ventilation; genetic susceptibility; air pollutant toxicology | | Weaver, Virginia | EHS/OEH | Associate Professor | Molecular epidemiology involving biomarkers for metals exposure and renal outcomes; occupational and environmental nephrotoxicants, particularly lead, cadmium and mercury; gene-environment interaction | | Reproductive and Developmental Disease | | Brown, Terry | BMB/Repro Biol | Professor | Androgen; prostate; benign prostatic hyperplasia; testis; spermatogenesis | | Evans, Janice | BMB/Repro Biol | Associate Professor | Mechanisms of sperm-egg membrane binding and fusion; oocyte maturation | | Zirkin, Barry | BMB/Repro Biol | Professor | Leydig cells; reactive oxygen species (ROS); ROS scavenging molecules; stem Leydig cells; environmental antiandrogens; fetal basis of adult disease |
* The departments of Environmental Health Sciences (EHS), Biochemistry and Molecular Biology (BMB) and Epidemiology (EPI) are in the School of Public Health. EHS is an interdisciplinary department with four divisions/program areas: Environmental Health Engineering (EHE), Occupational & Environmental Health (OEH), Physiology (PHYS), and Toxicology (TOX). ** Drs. Baylin and Casero have primary appointments in the Departments of Oncology and Comparative Medicine in the School of Medicine, and joint appointments in EHS/Toxicology. |