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Center on the Early Life Origins of Disease

 

 
 

Projects

Established Study Cohorts

COHORTS

Boston Birth Cohort

Chinese Twin Cohort

Chicago Family Cohort

Enrollment Summary

8,500 mother-infant pairs
(~2,500 preterm)

2,000 twin pairs
MZ: DZ ratio 1:1
6 years and older

1,300 families
Biological parents
and children 0-21 yr

Demographics

Inner city, minority (65% blacks, 25% Hisp)
in Boston

Homogeneous
Rural Chinese

White, suburb
In Chicago Area

Timepoints

Enrolled at Birth
F/U at pediatric primary care visits

Baseline
6 yr follow-up

Baseline

Data Collected

Prenatal and Perinatal EMR Data
Clinical Measurements including Growth and Development at F/U

Biospecimens: Maternal and Cord Blood, Placenta Tissue;
Venous Blood at F/U

Epidemiological Questionnaires

Clinical Measurements including Bone Density

Biospecimens: Blood, Urine, Stool

Epidemiological Questionnaires

Clinical Measurements including Allergy Testing

Biospecimens: Blood (All Enrolled Family Members)

Epidemiological Questionnaires

OPEN AND RECENTLY COMPLETED STUDIES

Boston Birth Cohort

  • Preterm Birth
    • 2R01 HD041702 NICHD Genome-wide Association Study of Preterm Birth
    • R21HD066471 NICHD Epigenome Association Study of Preterm Birth
       
  • Respiratory Diseases
    • K23 HL093023, NHLBI, Role of Prenatal Factors and Gene-Environment Interactions in Recurrent Wheezing
    • K23 HL093302 NHLBI, Oxidant Stress and Gene Polymorphisms in Bronchopulmonary Dysplasia
       
  • Food Allergy
    • FA093009, U.S. DOD, Genetics, Epigenomics and Food Allergy
    • R21AI088609, NIAID, Epigenome Association Study of Food Allergy
    • U01AI090727, NIAID, Post Genome-Wide Association Study of Food Allergy
       
  • Developmental Outcomes
    • R40 MC27443 HRSA A Prospective Birth Cohort Study on Pre- and Peri-natal Determinants of Autism Spectrum Disorders and Developmental Disabilities

Chinese Twin Cohort

  • R01 HD049059 NICHD, Epidemiology of Metabolic Syndrome in Children
  • R01 HL0864619 NHLBI, Sleep and Adiposity: A Prospective Twin Study
  • R01 AG032227 NIA, Establishing the Precursors of Osteoporosis in Children

Chicago Family Cohort

  • Food Allergy Research and Education, Molecular Epidemiology of Food Allergy, Data Administration and Analysis Core
  • R56AI080627, NIAID Genome-Wide Association Study of Food Allergy
  • R21AI088609, NIAID, Epigenome Association Study of Food Allergy
  • U01AI090727, NIAID, Post Genome-Wide Association Study of Food Allergy
  • K23AI103187, NIAID, Genetic and Environmental Determinants of Food Allergy

Other Cohorts

  • R03 ES022790 NIEHS, Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes from Female Textile Workers


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