340.670.11 GENETIC EPIDEMIOLOGY IN POPULATIONS
June 10-14, 2013
9:00 a.m. – 12:30 p.m.
This course will cover designs and methods for genetic epidemiology studies of unrelated individuals. Several population genetics concepts relevant to understanding genetic epidemiology designs and statistical tools will be introduced including concepts of quantitative and qualitative traits, genetic risk models, allele/haplotype frequency estimation, and migration/admixture. Methods for the evaluation of single and multiple genetic loci in the context of direct and indirect (linkage disequilbrium) associations with human disease will then be addressed, with examples from genome-wide, candidate gene and sequencing approaches. Methods for gene-gene and gene-environment interaction assessment will also be presented. The lecture material will be supplemented with examples using public and simulated data and currently available free software. Enrollment limited; students are required to bring a laptop computer to the class.
Student Evaluation: Short exam and in class polls
- Understand the concept of alleles, genotypes, and the Hardy-Weinberg principle and how to estimate allele and genotype frequencies.
- Understand the concept of allelic association and linkage disequilibrium and how to estimate LD measures and test for departures from equilibrium.
- Apply the above concepts to genetic association studies of unrelated individuals via candidate gene or genome-wide designs with a focus on either common or rare genetic variants.
- Apply concepts and software tools to address potential confounding by genetic ancestry in genetic epidemiological studies.
Class Times: Mon 06/10/2013 - Fri 06/14/2013
· Monday 9:00 - 12:30
· Tuesday 9:00 - 12:30
· Wednesday 9:00 - 12:30
· Thursday 9:00 - 12:30
· Friday 9:00 - 12:30
Prerequisite: Basic knowledge of epidemiology and biostatistics
Grading Options: Letter Grade or Pass/Fail
Course Materials: Provided in class and through CoursePlus