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Environmental Health Sciences

The Wang Laboratory of Human Environmental Epigenomes

auto immune
Auto immune Diseases
Recently, we began to work on single-cell RNA-seq to tackle some really interesting questions. These global strategies allow us to make a final conclusion based on the genome-wide analysis data.
HDAC's
A Model of Dancing With the Enemy
Co-repressor HDACs are in association with active genes but not widely assumed silent genes for transcriptional regulation. Two groups of enzymes (HATs and HDACs) with antagonizing functions therefore dance together at active genes.
Histone Code
Histone
Based on results of comprehensive profiling of 39 histone modification marks, we provided the first glimpse of what kind of histone “code” exists in the human genome.

Introduction

Meet Our Team

Lab Opportunities

Contact

  • zwang47@jhu.edu
  • Office: 410-955-7840 Lab: 410-614-5049
  • 615 North Wolfe Street, Baltimore, Maryland 21205
    Office: E7618  |  Lab: W7710

Research Goals

The long-term goal of the Wang laboratory is to determine how epigenetic codes, including patterns of DNA methylation and combinatorial patterns of simultaneously occuring histone modifications, are established and how this establishment goes awry upon environmental stimuli, thus contributing to human diseases (such as cancers and autoimmune diseases).

The Wang Laboratory of Human Environmental Epigenomes is housed in the Department of Environmental Health Sciences at the Johns Hopkins Bloomberg School of Public Health. Dr. Wang teaches courses as part of the PhD Track in Toxicology, Physiology & Molecular Mechanisms, and teaches a lecture in the course, The Molecular Basis of Environmental Health.