Biochemistry and Molecular Biology
615 N. Wolfe Street, W3606
Baltimore , Maryland 21205
PhD, University of Rochester, 1969
One major research focus is on the molecular regulation of Leydig cell steroidogenic function and DNA damage/repair during aging; and in particular on the role oxidative stress resulting from increased production of reactive oxygen and decreases in cellular antioxidant defenses. A second research focus on the stem cells that ultimately give rise to adult Leydig cells, and on the issue of whether and how stem cells age. A third focus is on the regulation of mammalian spermatogenesis and its tranlation to male infertility and contraception. Finally, we are examining the effect of fetal exposure to phthalates on steroidogenic function later in life.
Leydig cell aging spermatogenesis reproductive toxicology