Johns Hopkins Asthma & Allergy Center, 4B.77
Baltimore , Maryland
1) Hypoxic Pulmonary Vasoconstriction. The acute pulmonary vasoconstrictor response to hypoxia optimizes local oxygen exchange in normal lungs, but can contribute to pulmonary hypertension, corpulmonale, and mortality in patients with diffuse lung disease or in subjects exposed to high altitude. My work seeks to promote understanding of in vivo hypoxic pulmonary vasoconstriction by clarifying the mechanisms responsible for direct effects of hypoxia on pulmonary arteries, arterial myocytes, and arterial endothelium observed in vitro. 2) Ischemia-Reperfusion Injury in Isolated Lungs. These studies will attempt to determine the mechanisms by which ischemia and reperfusion injure the isolated lung and whether these mechanisms are relevant to ischemia-reperfusion lung injury in in vivo animals.
Hypoxic Pulmonary Vasoconstriction Ischemia-Reperfusion Injury in Isolated Lungs