Philip Jordan

Philip Jordan

Assistant Professor

Departmental Affiliation(s):

Biochemistry and Molecular Biology (Primary)

BMB webpage: http://www.jhsph.edu/departments/biochemistry-and-molecular-biology/faculty/recently-recruited-faculty/philip-jordan

Education

PhD, University of Edinburgh

Overview

Our goal is to decipher the mechanisms required for successful transmission of the genome from one generation to the next. For the formation of genetically normal sperm and eggs, chromosomes must segregate accurately during a specialized cell cycle known as meiosis. However, approximately 10% of clinically reported pregnancies are chromosomally abnormal, resulting in pregnancy loss or genetic defects such as Down syndrome [Hassold and Hunt, Nature Reviews Genetics (2001), Vol. 2 (4) p280]. Meiosis involves chromosome replication and two rounds of chromosome segregation (meiosis I and II), resulting in the formation of up to four haploid gametes (sperm and egg). Meiosis I differs from mitosis because homologous chromosomes segregate, whereas sister chromatids remain associated until meiosis II. For successful chromosome segregation during meiosis I, homologous chromosomes need to become linked. Linkage occurs during meiotic prophase I via two co-ordinated events: 1) homologous recombination which repairs endonuclease-induced DNA double-strand breaks and 2) the formation the synaptonemal complex, a zipper-like protein complex that is synthesized between homologous chromosomes. Our lab uses budding yeast and the mouse as model organisms to determine the mechanisms that orchestrate DNA recombination and synaptonemal complex dynamics with homologous chromosome segregation.   CURRENT LAB MEMBERS: Philip Jordan - Principle Investigator Marina Pryzhkova - Postdoctoral researcher Chantal Sottas - Research Specialist Grace Hwang - 2nd year PhD student Jessica Hopkins - 1st year PhD student Dennis Orkoulas-Razis - Masters of Health Science student Ayobami Ward - Masters of Health Science student  

Honors and Awards

  2014: Ho-Ching Yang Memorial Faculty Fellowship in Cancer Prevention 2013: R00 NIH Pathway to Independence Award, NICHD 2011: K99 NIH Pathway to Independence Award, NICHD 2010: US-UK Fulbright Distinguished Scholar Award, US-UK Fulbright Commission 2006: Federation of European Biochemical Societies Research Award 2005: Society for General Microbiology President’s Research Award and post-funding prize 2005: European Unions’ ERASMUS Student Mobility Award 2004: British Council - Austrian Academic Research Collaboration Award 2002: Darwin Trust International PhD Scholarship, University of Edinburgh, Scotland  

Research Interests

Genome maintenance Meiosis DNA recombination Chromosome segregation Structural Maintenance of Chromosomes (SMC) SMC5/6 Synaptonemal complex Polo-like kinase (PLK) Cohesin Aurora kinase (AURK)