Janet Holbrook

Janet Holbrook

Associate Professor

Departmental Affiliation(s):

Epidemiology (Primary)

Contact Information

911 S. Ann Street
Baltimore , Maryland   21231



PhD, Johns Hopkins University, 1999
MPH, University of California, Berkeley, 1988


My primary interest is in the design, conduct, and analysis of multicenter clinical trials.  Many of the trials we have completed are comparative effectiveness trials - head to head comparisons of competing treatment with patient-centered outcomes. Most of my experience has been in trials of treatments for eye disease and asthma.     

Research Interests

Epidemiology, clinical trials, surrogate outcomes, prospective observational studies. asthma, uveitis


  • Holbrook JT, Wise RA, Gold BD, Blake K, Brown ED, Castro M, Dozor AJ, Lima JJ, Mastronarde JG, Sockrider MM, Teague WG.  Lansoprazole for children with poorly controlled asthma: a randomized clinical trial.  in Children with Asthma.  JAMA 2012; 307(4): 1-9.
  • Holbrook JT, Kempen JH, Prusakowski NA, Altawel MM, Jabs DA.  Challenges in the design and implementation of The Multicenter Uveitis Steroid Treatment (MUST) Trial – Lessons for Comparative Effectiveness Trials.  Clinical Trials 2011;8(6):736-743.
  • Kempen JH, Altaweel MM, Holbrook JT, Jabs DA, Louis TA, Sugar EA, Thorne JE. Randomized comparison of systemic anti-inflammatory therapy versus flucinolone actinide intraocular implant for intermeadiate, posterior and panuveitis: The Multicenter Uveitis Treatment Trial.  Ophthalmology 2011;118(10):736-743.
  • Holbrook JT, Colvin R, Van Natta ML, Thorne JE, Bardsley M, Jabs DA.  Evaluation of the United States Public Health Service guidelines for discontinuation of anti-CMV therapy after immune recovery in patients with CMV retinitis.  Am J Ophthalmology 2011;142(4):628-637.
  • Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. The MUST Trial: rational, design and baseline characteristics. 2010;149:550-561.