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340.732.01 PRINCIPLES OF GENETIC EPIDEMIOLOGY 2

Department:
Epidemiology
Term:
2nd term
Credits:
3 credits
Academic Year:
2013 - 2014
Location:
East Baltimore
Class Times:
  • Tu Th,  9:00 - 10:20am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Terri Beaty
Course Instructor:

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Description:

Second offering in a four-quarter series. Details the concepts of linkage disequilibrium, haplotypes, and the use of public information to inform study design and analysis related to haplotypes. Presents genetic association analyses of quantitative and qualitative disease-related phenotypes for both unrelated and family-based sampling designs. Reviews the concepts and tools related to confounding by ancestry, approaches for genome-wide association studies and for assessment of gene-by-gene and gene-by-environment interactions; and methods for genetic linkage analysis. Select class sessions are dedicated to discussion-based and computer-based labs to further illustrate the methods taught.

Learning Objectives:

After completing this course, you should be able to:

  1. Demonstrate the concepts of linkage disequilibrium and haplotypes
  2. Calculate LD coefficients and haplotype frequencies
  3. Explain the utility of the HapMap project and the 1000Genomes project
  4. Use public databases to select tagSNPs or estimate LD coverage
  5. Describe the various design strategies for genetic studies and discuss the advantages and disadvantages of each
  6. Explain the difference between genetic association and genetic linkage
  7. Perform genetic association tests in family-based and unrelated samples
  8. Discuss the concept of confounding by ancestry in genetic analyses
  9. Apply tools to adjust for confounding by ancestry
  10. Perform estimation and tests of gene-by-gene and gene-by-environment interactions
  11. Apply the above concepts in the context of genome-wide association studies
  12. Perform and interpret linkage analyses on family data
Methods of Assessment:
Student evaluation based on class participation, homework and a final exam.
Instructor Consent:
Consent required for all students
Consent Note:

Consent required for all students

For consent, contact:
tbeaty@jhsph.edu
Prerequisite:

introduction to genetics course