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340.732.01 PRINCIPLES OF GENETIC EPIDEMIOLOGY 2

Department: Epidemiology
Term: 2nd term
Credits: 3 credits
Contact: Dani Fallin
Academic Year: 2012 - 2013
Course Instructors:
Description:

Second offering in a four-quarter series. Details the concepts of linkage disequilibrium, haplotypes, and the use of public information to inform study design and analysis related to haplotypes. Presents genetic association analyses of quantitative and qualitative disease-related phenotypes for both unrelated and family-based sampling designs. Reviews the concepts and tools related to confounding by ancestry, approaches for genome-wide association studies and for assessment of gene-by-gene and gene-by-environment interactions; and methods for genetic linkage analysis. Select class sessions are dedicated to discussion-based and computer-based labs to further illustrate the methods taught.

Learning Objective(s):
After completing this course, you should be able to:
Demonstrate the concepts of linkage disequilibrium and haplotypes
Calculate LD coefficients and haplotype frequencies
Explain the utility of the HapMap project and the 1000Genomes project
Use public databases to select tagSNPs or estimate LD coverage
Describe the various design strategies for genetic studies and discuss the advantages and disadvantages of each
Explain the difference between genetic association and genetic linkage
Perform genetic association tests in family-based and unrelated samples
Discuss the concept of confounding by ancestry in genetic analyses
Apply tools to adjust for confounding by ancestry
Perform estimation and tests of gene-by-gene and gene-by-environment interactions
Apply the above concepts in the context of genome-wide association studies
Perform and interpret linkage analyses on family data

Methods of Assessment: Student evaluation based on class participation, homework and a final exam.
Location: East Baltimore
Class Times:
  • Tuesday 9:00 - 10:20
  • Thursday 9:00 - 10:20
Enrollment Minimum: 10
Instructor Consent: Consent required for all students

Consent required for all students

For consent, contact: dfallin@jhsph.edu
Prerequisite:

introduction to genetics course

Auditors Allowed: Yes, with instructor consent
Grading Restriction: Letter Grade or Pass/Fail