Skip Navigation

Course Catalog

340.731.81 PRINCIPLES OF GENETIC EPIDEMIOLOGY

Description:

First in a four-term series. Presents fundamental concepts and methods in genetic epidemiology. Reviews basic terminology of genetics, introduces basic principles of population genetics, and provides an overview of various genetic epidemiology study designs, covering basic analysis, inferences, plus their strengths and limitations. Presents methods for assessing familial aggregation/correlation, and covers statistical techniques for modeling inheritance of complex phenotypes on family data. Presents both linkage and association analyses, with emphasis on how these are used in genetic epidemiology. Explains different study designs commonly used in genetic epidemiology to identify the genetic basis of common, complex diseases.

Learning Objective(s):
Upon successfully completing this course, students will be able to:
Present fundamental concepts and methods in genetic epidemiology
Discuss and give examples of different types of study designs used in the field of genetic epidemiology
Discuss and give examples of different types of study designs used in the field of genetic epidemiology; be familiar with basic terminology in the field of human genetics
Discuss the basic principles behind major molecular biology techniques, such as PCR, and their applications in genetic epidemiology studies
Discuss various exposures, or markers, used in genetic epidemiology studies
Discuss principles of Hardy-Weinberg Equilibrium and be able to estimate allele and genotype frequencies
Discuss and calculate simple statistics, such as odds ratios and LOD scores
Discuss the difference between linkage and association studies
Discuss the difference between family-based and population-based studies
Discuss the difference between direct and indirect association studies
interpret results of a linkage study
interpret results of an association study
select an appropriate study design for addressing a particular question
Discuss the inferences drawn from the different genetic epidemiology studies

Methods of Assessment: Student evaluation based on homework and exams.
Location: Internet
Enrollment Minimum: 10
Instructor Consent: No consent required
Prerequisite:

Introduction to Online Learning is required prior to participating in any of the School's Internet-based courses. and College-level biology or genetics.

Auditors Allowed: Yes, with instructor consent
Grading Restriction: Letter Grade or Pass/Fail