340.632.01 METHODS FOR LINKAGE ANALYSIS IN GENETIC EPIDEMIOLOGY
- Alison Klein
- Priya Duggal
Covers the principles of linkage analysis and introduction to sequencing as used in studies of complex diseases, where both genes and environmental risk factors influence risk. Addresses the principles of both singlepoint and multipoint linkage analysis using ‘model based’ and ‘model free’ statistical methods. Examines the interpretation of genome wide linkage analysis with a particular emphasis on complex and heterogeneous diseases. Introduces the methods for identifying linkage heterogeneity and covariate effects on evidence from linkage analysis as well as combined tests of linkage and linkage disequilibrium in family based tests. Also addresses basic sequencing methods.
- Tuesday 9:00 - 10:20
- Thursday 9:00 - 10:20
340.631, 140.621-622 or 140.651-652; 340.664