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340.632.01 METHODS FOR LINKAGE ANALYSIS IN GENETIC EPIDEMIOLOGY

Discontinued

Department:
Epidemiology
Term:
4th term
Credits:
3 credits
Academic Year:
2013 - 2014
Location:
East Baltimore
Class Times:
  • Tu Th,  9:00 - 10:20am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Priya Duggal
Course Instructors:

Visit the CoursePlus site for this course

Prerequisite:

340.631, 140.621-622 or 140.651-652; 340.664

Description:

Covers the principles of linkage analysis and introduction to sequencing as used in studies of complex diseases, where both genes and environmental risk factors influence risk. Addresses the principles of both singlepoint and multipoint linkage analysis using ‘model based’ and ‘model free’ statistical methods. Examines the interpretation of genome wide linkage analysis with a particular emphasis on complex and heterogeneous diseases. Introduces the methods for identifying linkage heterogeneity and covariate effects on evidence from linkage analysis as well as combined tests of linkage and linkage disequilibrium in family based tests. Also addresses basic sequencing methods.

Methods of Assessment:

Computer-based homework assignments and written critiques of relevant articles from the scientific literature.

Instructor Consent:

Consent required for some students

Consent Note:

Auditors and those without pre-requisites

For consent, contact:

pduggal@jhsph.edu

Jointly Offered With: