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330.619.01 ANALYTIC STRATEGIES IN THE GENETICS OF PSYCHIATRIC, BEHAVIORAL AND OTHER COMPLEX DISEASES

Department: Mental Health
Term: 4th term
Credits: 3 credits
Contact: Brion Maher
Academic Year: 2013 - 2014
Course Instructor:
Description:

Addresses the rapidly changing landscape of the study of complex genetics diseases. Students explore the current state of the quantitative issues in complex disease genetics, so that they can translate their experiences into research practice. Analyzes genome-wide association scans, epigenetics, and next-generation sequencing, as well as approaches to power calculation, including the use of simulation. Students study the current literature as well as examples from real data sets. In addition to learning the analytic techniques, students also become familiar with the assumptions and limitations of these approaches.

Learning Objective(s):
After completing this course, you should be able to:
Analyze data from genome-wide or candidate methylation studies
Perform Systems-Based and Polygenic Analyses from Genome-wide Association Data
Perform Genetic Association Studies Using Data Generated Next Generation Sequencing
Perform Power Calculations for Genetic Association Studies
Apply Simulation-based Approaches to Calculate Statistical Power or Emipirical Significance to Genetic Studies

Methods of Assessment: Exams and a Project
Location: East Baltimore
Class Times:
  • Monday 10:30 - 11:50
  • Wednesday 10:30 - 11:50
Enrollment Minimum: 10
Instructor Consent: No consent required
Auditors Allowed: Yes, with instructor consent
Grading Restriction: Letter Grade or Pass/Fail