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330.619.01 ANALYTIC STRATEGIES IN THE GENETICS OF PSYCHIATRIC, BEHAVIORAL AND OTHER COMPLEX DISEASES

Department:
Mental Health
Term:
4th term
Credits:
3 credits
Academic Year:
2013 - 2014
Location:
East Baltimore
Class Times:
  • M W,  10:30 - 11:50am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Brion Maher
Course Instructor:

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Description:

Addresses the rapidly changing landscape of the study of complex genetics diseases. Students explore the current state of the quantitative issues in complex disease genetics, so that they can translate their experiences into research practice. Analyzes genome-wide association scans, epigenetics, and next-generation sequencing, as well as approaches to power calculation, including the use of simulation. Students study the current literature as well as examples from real data sets. In addition to learning the analytic techniques, students also become familiar with the assumptions and limitations of these approaches.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Analyze data from genome-wide or candidate methylation studies
  2. Perform systems-based and polygenic analyses from genome-wide association data
  3. Perform genetic association studies using data generated next generation sequencing
  4. Perform power calculations for genetic association studies
  5. Apply simulation-based approaches to calculate statistical power or empirical significance to genetic studies
Methods of Assessment:

Exams and a Project

Instructor Consent:

No consent required