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Course Catalog



Term: 4th term
Credits: 3 credits
Contact: Noel Rose
Academic Year: 2013 - 2014

Presents the genetic basis of immune responsiveness. Reviews the genetic mechanisms responsible for generation of diversity in the genes for immunoglobulins, the T cell receptor molecules, the major histocompatibility molecules, and other key molecules of the immuno-globulin superfamily. Discusses mechanisms and statistical evaluation of immunogenetic associations with susceptibility or resistance to disease.

Learning Objective(s):
Upon successfully completing this course, students will be able to:
Define the genetic systems that encode molecules with integral roles in immune regulation
Assess the impact of allelic polymorphism in certain genes on features such as gene expression and MHC restriction
Define the basic mechanisms for expansion of the immunologic repertoire of antigen receptors
Understand the implications of population differences in the frequencies of genes involved in immune responses

Methods of Assessment: Student evaluation based on a mid-term exam, and a final exam, or paper and oral presentation.
Location: East Baltimore
Class Times:
  • Tuesday 1:30 - 2:50
  • Thursday 1:30 - 2:50
Enrollment Minimum: 6
Instructor Consent: No consent required

260.611-612 or introductory course in immunology; introductory course in genetics

Auditors Allowed: Yes, with instructor consent
Grading Restriction: Letter Grade or Pass/Fail
Frequency Schedule: