260.714.01 IMMUNOGENETICS

Presents the genetic basis of immune responsiveness. Reviews the genetic mechanisms responsible for generation of diversity in the genes for immunoglobulins, the T cell receptor molecules, the major histocompatibility molecules, and other key molecules of the immuno-globulin superfamily. Discusses mechanisms and statistical evaluation of immunogenetic associations with susceptibility or resistance to disease.

1. Define the genetic systems that encode molecules with integral roles in immune regulation. 2. Assess the impact of allelic polymorphism in certain genes on features such as gene expression and MHC restriction. 3. Define the basic mechanisms for expansion of the immunologic repertoire of antigen receptors. 4. Understand the implications of population differences in the frequencies of genes involved in immune responses.