260.611.01 PRINCIPLES OF IMMUNOLOGY I

Introduces biological concepts of immunology; molecular nature of antigens; molecular basis for antibody and T-cell receptor structure and diversity; complement; hypersensitivity reactions; cellular basis for the immune response; cell-mediated immunity; adhesion molecules and coreceptors cell activation; cytokines and other soluble mediators; major histocompatibility complex (MHC) antigens; tumor immunology; transplantation immunobiology; mechanisms of resistance to microorganisms; tolerance; autoimmunity; and immuno-deficiency.

• Define the tissue, cellular and molecular components that constitute the vertebrate innate and adaptive immune system. • Explain the generation of lymphocyte antigen receptors and the molecular and cellular basis for diversity and specificity of receptors on immune cells. • Define the basis for antigen presentation to T cells • Define the basis for recognition of self and non-self recognition. • Define the development and survival of lymphocytes • Explain the major signaling pathways used by immune cells • Define T cell-mediated and B cell-mediated immunity