260.608.01 ADVANCED TOPICS IN AIDS RESEARCH

Introduces students to the HIV lifecycle and the molecular events occurring during productive infection. Covers topics including the HIV life cycle (Entry, Reverse transcription, Integration, Assembly, Budding, and Maturation), viral regulatory proteins, host innate anti-HIV responses (Apobec and Trim5á), immune responses induced by vaccine and infection, recent progress in HIV vaccine development, origins of HIV, SIV, endogenous retroviruses, new insights in HIV pathogenesis, host factors influencing disease outcome, latency and persistence, transmission, and prophylactic strategies of prevention.

Upon successfully completing this course, students will be able to: • define points of the viral lifecycle at which host proteins interfere with viral infection • understand replication cycle of HIV and contrasts with other retroviruses • assess current vaccine strategies • analyze current literature • explain the influence of host factors on disease outcome