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223.690.01 THE DESIGN AND ANALYSIS OF CLUSTER RANDOMIZED TRIALS

Department: International Health
Term: 4th term
Credits: 2 credits
Contact: Lawrence Moulton
Academic Year: 2013 - 2014
Course Instructor:
Description:

Covers the major concepts and methods in the design and analysis of trial in which the unit of randomization is a group of participants. Focuses on design: discusses unmatched, matched, stepped wedge, and other approaches, with particular attention paid to randomization and sample size considerations. Presents a variety of methods for the analysis of these correlated-outcomes studies. Includes special aspects of infectious disease interventions.

Learning Objective(s):
Upon successfully completing this course, students will be able to:
Identify when a cluster randomized trial may be preferable to an individually randomized trial.
Determine optimal design strategies for enabling estimation of efficacy and effectiveness parameters of interest.
Conduct and interpret statistical analyses appropriate to these designs.

Methods of Assessment: 60% weekly exercises, 40% short project paper outlining a new trial with critical features and options discussed.
Location: East Baltimore
Class Times:
  • Tuesday 3:30 - 5:20
Enrollment Minimum: 6
Enrollment Maximum: 25
Instructor Consent: No consent required
Prerequisite:

Biostatistics 621, 622, 623, 624 or equivalent sequence.

Auditors Allowed: Yes, with instructor consent
Grading Restriction: Letter Grade or Pass/Fail