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223.689.01 BIOLOGIC BASIS OF VACCINE DEVELOPMENT

Department: International Health
Term: 4th term
Credits: 3 credits
Academic Year: 2012 - 2013
Course Instructors:
Description:

Provides an overview of the biologic basis for development and evaluation of new viral, bacteriologic, parasitic, and cancer vaccines. Lectures address the fundamental immunologic concepts of correlates of protective immunity underlying current and new strategies for immunization. Emphasizes the use of new technologies for expression of vaccine antigens, including recombinant DNA techniques and use of novel adjuvants and antigen-carrier systems to enhance the delivery/presentation of specific immunogens to effector sites.

Learning Objective(s):
Upon successfully completing this course, students will be able to:
Identify and describe the biological obstacles preventing development of effective vaccines for several important human pathogens
Identify, analyze, and critique cutting-edge strategies for approaching these obstacles
Describe several molecular mechanisms by which various adjuvants may potentiate vaccine induced immune responses
Identify and explain multiple differences between the natural immune response to pathogens and the vaccine induced immune response to targeted antigens
Analyze and explain the implications for bio-defense of vaccine related work on various pathogens
Describe the advantages and disadvantages of several viral and bacterial vectors for the delivery of recombinant vacine antigens or DNA
Discuss the three signals necessary to trigger a primary immune response to a candidate vaccine antigen
Discuss the important role that vaccine type (ie live vs killed vs subunit) and route of administration (IM vs ID) can play in determining the types of immune responses elicited by immunization

Methods of Assessment: Student evaluation based on mid-term and final exams.
Location: East Baltimore
Class Times:
  • Monday 3:30 - 4:50
  • Wednesday 3:30 - 4:50
Enrollment Minimum: 8
Instructor Consent: No consent required
Prerequisite:

260.611-612, or equivalent knowledge of principles of modern immunology

Grading Restriction: Letter Grade or Pass/Fail
Jointly Offered With:
  • Molecular Microbiology and Immunology