260.627.01 Pathogenesis of Bacterial Infections
- Molecular Microbiology and Immunology
- 3rd term
- 4 credits
- Academic Year:
- 2014 - 2015
- East Baltimore
- Class Times:
- M W F, 10:30 - 11:50am
Presents the mechanism employed by bacteria to establish and maintain infection in the human host and evolution of host resistance mechanisms. Covers host-pathogen relationship, bacterial structure and metabolism, pathogenic mechanisms of bacteria, systemic and mucosal immunity, major Gram-negative and Gram-positive bacterial pathogens, antibiotic resistance, bacterial vaccines, and role of microbiome in health and disease. Discussions generally cover Gram-negative and Gram-positive bacteria with specific lectures on pathogens of particular interest, such as mycobacteria, H. pylori, Borrelia, rickettsia, and bacteria associated with sexually transmitted diseases. Complemented by two clinical plate rounds and a clinical lab tour that aims to give a flavor of clinical relevance of the covered topics.
- Learning Objectives:
- Analyze unique features of bacterial cells compared with eukaryotic cells, and the structure/function and metabolism of the bacterial cell needed for understanding the molecular basis of bacterial pathogenesis
- Assess how bacteria mediate genetic exchanges and the genetic strategies used to dissect bacterial virulence factors, and molecular Koch postulates for verifying the role of a given gene in bacterial pathogenesis
- Define the pathogenic mechanisms bacteria use to cause disease
- Define how antibiotics work and how bacteria develop two types of resistances to antibiotics and the role of persisters in relapse of persistent bacterial infections
- Define the importance of microbiome in human health and diseases
- Define host immune mechanisms in controlling bacterial infections and how vaccine works
- Assess methods of diagnosis and treatment of major select bacterial pathogens
- Methods of Assessment:
Student evaluation based on homework (20%), a mid-term (40%), and a final exam (40%).
- Instructor Consent:
No consent required
- Special Comments:
Required for MMI students.