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Course Catalog

187.655.01 EVIDENCE-BASED TOXICOLOGY

Department:
Environmental Health Sciences
Term:
4th term
Credits:
3 credits
Academic Year:
2015 - 2016
Location:
East Baltimore
Class Times:
  • M W,  1:30 - 2:50pm
Auditors Allowed:
No
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Thomas Hartung
Course Instructors:

Visit the CoursePlus site for this course

Prerequisite:

187.610 Public Health Toxicology

Description:

The National Toxicology Program, the Environmental Protection Agency and authorities worldwide, increasingly embrace the concepts of systematic reviews, meta-analysis, risk-of-bias, and quality assurance. Evidence-based toxicology (EBT) is a rapidly evolving discipline that represents a way to transparently and consistently evaluate scientific evidence, which can then be applied to address critical questions in toxicology. EBT is especially useful in the fields of regulatory toxicology and risk assessment, where numerous studies must be considered, weighed and integrated to support decision-making.

Provides students with fundamental knowledge about EBT approaches currently in use (or in development) that integrate and utilize diverse sources of data. These approaches include meta-analysis and systematic reviews, as used in evidence-based medicine. Introduces, explains and expands upon techniques such as risk of bias, QA/QC, good laboratory practice and validation, and the role that these tools and techniques play in assuring maximum confidence in evidence-based approaches.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Discuss the advantages of evidence-based and bioinformatics approaches
  2. Describe the principles of systematic review and meta-analysis
  3. Explain quality assurance schemes in scientific work
  4. Explain the basis of validation processes
  5. Identify reasons for bias in scientific work
  6. Apply quality scoring to published studies
Methods of Assessment:

40% two exams, 40% assignment, 20% participation in discussion forum and LiveTalk

Instructor Consent:

Consent required for some students

Consent Note:

students not in the MSPH Program Track require instructor consent

For consent, contact:

thartun1@jhu.edu