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187.632.01 ENVIRONMENTAL HEALTH: THE MOLECULAR BASIS

Department:
Environmental Health Sciences
Term:
2nd term
Credits:
4 credits
Academic Year:
2012 - 2013
Location:
East Baltimore
Class Times:
  • M W F,  10:30 - 11:50am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Shyam Biswal
Course Instructors:

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Prerequisite:

187.610 and a basic course in molecular biology or consent of instructor.

Description:

Reviews the mechanisms of environmental diseases at the molecular and genetic levels through faculty lectures and discussion of scientific papers. Presents most recent technological advances in the molecular and genetic tools available to study environmental diseases, which includes omics technologies (proteomics, genomics and metabolomics), microarray, nextgen sequencing for genetic variations (SNPs), bioinformatics, transgenic animals and emerging alternative animal models. Topics include mechanisms and cell signaling pathways involved in oxidative, nitrosative stress and inflammation in response to exposure to air pollutants, metals and other environmental toxicants that causes non-communicable diseases such as cancer, lung and heart diseases. Addresses the impact of environmental toxicants on cell growth, cell death, DNA repair, epigenetics, inflammation and the multi-stages of carcinogenesis which cause major non-communicable diseases and impact public health.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Analyze and Discuss the literature regarding a wide array of topics relevant to molecular toxicology, including the molecular response to environmental stress and pathways of carcinogenesis and DNA repair
  2. Describe various gene-environment interactions that lead to either cell adaptation, cell death or disease in response to toxins in the environment
  3. Discuss the application of various state-of-the-art techniques for molecular analyses, including proteomics, genomics, bioremediation, surface plasma resonance, transgenic animals for research and polymorphism monitoring
Methods of Assessment:

Total grade will be based on midterm and final exams and attendance.

Instructor Consent:

No consent required