187.630.01 XENOBIOTIC METABOLISM AND BIOMARKER DEVELOPMENT

Focuses on the metabolism of xenobiotics and on toxicokinetics and dynamics and is largely literature-based. Discusses pathways and concepts of xenobiotic metabolism thru review of the literature inside and outside the classroom, and applies concepts thru classroom discussion of pertinent research papers. Emphasizes experimental design with analytical techniques, and incorporates strategies for writing and evaluating laboratory research grants. Prepares PhD students for a career in toxicology laboratory research.

Upon successful completion of this course, students should be able to: in a oral and written format (i) describe xenobiotic metabolism pathways and concepts of toxicokinetics/dynamics, (ii) design experiments using various analytical techniques, (iii) define the process of writing and evaluating research grants.