187.620.01 ENVIRONMENTAL TOXICOLOGICAL PATHOLOGY

Focuses on pathophysiology and pathologic responses of toxicity induced by toxins of the cardiovascular, pulmonary, reproductive, neurological, immune, and gastrointestinal systems. A review of normal histology for the specific organ systems is compared to examples of acute and chronic toxicity to illustrate light microscopic and ultrastructural damage with correlation to altered physiology and function. The course integrates into each organ system studied a review of standard techniques used in toxicity studies including the use of animal necropsy, histology/pathology, various tissue molecular biological techniques, transgenic mice, and noninvasive physiological monitoring.

At the end of this course, you will be able to: - Describe the mechanism of toxicity behind multiple case examples. - In the context of these case examples: you will become familiar with normal histology of the heart, lung, ovary, testes, brain, spinal cord, lymph nodes, spleen, bone marrow, pancreas, liver and GI tract. - Describe basic histopathological lesions associated with case examples in cardiovascular, pulmonary, reproductive, neurological, immune, and gastrointestinal systems. -perform an animal necropsy.