260.655.01
Protein BioInformatics and Structure
Course Status
Cancelled
Course Status
Cancelled
Location
East Baltimore
Term
4th Term
Department
Molecular Microbiology and Immunology
Credit(s)
3
Academic Year
2013 - 2014
Instruction Method
TBD
Tu, Th, 3:30 - 4:50pm
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
No
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Course Instructor(s)
Juergen Bosch
Contact Name
Sean Prigge
Contact Email
Frequency Schedule
Every Other Year
Resources
Prerequisite
Introduction to Molecular Biology (120.602) or consent of instructor
Provides students with an overview of protein bioinformatics including computational and experimental approaches. Introduces amino acid and protein physical properties as well as the alignment and evolution of protein sequences. Presents protein structure and methods of structure determination as well as the use of protein databases and software for visualizing proteins and generating publication quality figures. Discusses methods for secondary and tertiary protein structure prediction including homology modeling. Also covers methods for modeling small/molecule-protein interactions within the context of rational drug discovery and design. Finally, introduces students to experimental and computational aspects of mapping protein interaction networks.
Learning Objectives
Upon successfully completing this course, students will be able to:
- Define protein physical properties and analyze protein structure
- Explain how proteins are studied experimentally and how data is generated in high- throughput experiments
- Describe the computational methods used to study protein structure and interactions
- Master the use of protein databases and protein modeling and visualization software
Jointly Offered With
Three Friday computer labs will provide students with practical experience with web-based tools.