340.632.01
Methods for Linkage Analysis in Genetic Epidemiology
Course Status
Discontinued
Course Status
Discontinued
Location
East Baltimore
Term
4th Term
Department
Epidemiology
Credit(s)
3
Academic Year
2013 - 2014
Instruction Method
TBD
Tu, Th, 9:00 - 10:20am
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
No
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Contact Name
Priya Duggal
Contact Email
Frequency Schedule
Every Year
Resources
Prerequisite
340.631, 140.621-622 or 140.651-652; 340.664
Covers the principles of linkage analysis and introduction to sequencing as used in studies of complex diseases, where both genes and environmental risk factors influence risk. Addresses the principles of both singlepoint and multipoint linkage analysis using ‘model based’ and ‘model free’ statistical methods. Examines the interpretation of genome wide linkage analysis with a particular emphasis on complex and heterogeneous diseases. Introduces the methods for identifying linkage heterogeneity and covariate effects on evidence from linkage analysis as well as combined tests of linkage and linkage disequilibrium in family based tests. Also addresses basic sequencing methods.
Jointly Offered With