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120.861.01 SPECIAL TOPICS IN BIOCHEMISTRY: X-RAY CRYSTALLOGRAPHY-A HANDS ON WORKSHOP

Department:
Biochemistry and Molecular Biology
Term:
Summer term
Credits:
3 credits
Academic Year:
2013 - 2014
Location:
East Baltimore
Dates:
Mon 08/05/2013 - Tue 08/13/2013
Class Times:
  • M Tu W Th F,  8:30am - 5:00pm
  • M Tu,  8:30am - 5:00pm

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Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Juergen Bosch
Course Instructor:
  • Juergen Bosch
Prerequisite:

Some basic knowledge of UNIX or Linux is desirable.

Description:

Enables students to carry out all key steps to successfully solve and refine a protein crystal structure. Theoretical aspects are followed by application to various problem sets. Topics include tricks for data collection, data processing and collection. Touches upon all standard techniques such as molecular replacement, SAD phasing and MAD phasing, both in theory and then applied in practical context with previously collected data. Identification of unknown ligand densities and model refinement lead to the last part of preparing publication quality figures using PyMol.

Methods of Assessment:

Students are evaluated on their participation in classroom discussions and also on completion of assigned homework and tutorial data.

Enrollment Restriction:

None

Instructor Consent:

Consent required for all students

Consent Note:

Permission of instructor required.

For consent, contact:

jubosch@jhsph.edu

Special Comments:

Students can visit http://lupo/jhsph.edu/boschlab/Xray_Workshop.html for updated information about the course.