120.624.01
Genome Integrity and Cancer
Location
East Baltimore
Term
4th Term
Department
Biochemistry and Molecular Biology
Credit(s)
3
Academic Year
2012 - 2013
Instruction Method
TBD
M, W, 3:30 - 4:50pm
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
No
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Contact Name
Frequency Schedule
Every Year
Resources
Prerequisite
Graduate level molecular biology, and biochemistry or the equivalent.
Examines molecular mechanisms devoted to the preservation of genome integrity eukaryotic cells. Topics include DNA damage recognition, DNA repair pathways, cell cycle checkpoint mechanisms, the role of p53 in DNA damage responses, the role of ubiquitination and sumoylation in DNA repair, telomere maintenance and DNA repair proteins as target for therapeutic intervention. Emphasizes the relevance of these mechanisms for human cancer.
Learning Objectives
This course will prepare you to be able to do the following:
- Understand how exposure to various environmental agents and anti-cancer drugs can lead to modifications of DNA
- Understand the mechanisms by which DNA repair proteins and enzymes maintain the integrity of the genome
- Understand how DNA protection and repair systems function in the context of the cell
- Understand the connections between DNA damage/DNA repair capacity and human disease, particularly cancer
Enrollment Restriction
Undergraduates prohibited from enrolling in this course.