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120.608.01
Genomics for Public Health

Location
East Baltimore
Term
4th Term
Department
Biochemistry and Molecular Biology
Credit(s)
3
Academic Year
2012 - 2013
Instruction Method
TBD
Class Time(s)
Tu, Th, 1:30 - 2:50pm
Lab Times
Tuesday, 1:30 - 2:50pm (01)
Thursday, 1:30 - 2:50pm (01)
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
No
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Contact Name
Frequency Schedule
Every Year
Prerequisite

A college level course in biology.

Description
Introduces genomics and modern genetic technologies, emphasizing their application to significant public health problems, to students who have limited prior coursework in molecular biology or molecular genetics. Integrates lectures and discussions with computer exercises in laboratory sessions. Topics include fundamental principles of molecular biology; genome sequencing and structure; gene cloning; mapping of human disease genes; use of DNA microarrays, protein microarrays, and next generation rapid DNA sequencing methodologies in analysis and treatment of human disease; comparative genomics of model and pathogenic organisms; epigenomics and metagenomics; and genetically modified organisms.
Learning Objectives
Upon successfully completing this course, students will be able to:
  1. Describe the organization of the human genome and the genomes of selected model organisms
  2. Explain how human disease genes are mapped
  3. Analyze DNA, RNA, or protein sequences through the use of public domain databases and algorithms
  4. Explain how DNA microarrays, protein microarrays, and rapid whole-genome-sequencing technologies can be used to analyze or treat human disease in individuals and populations
  5. Describe basic recombinant DNA, proteomic, and biotechnological methodologies used in the analysis of human disease
  6. Explain how modifications to chromatin or the presence of gut microbial flora impact expression of selected human genes.