340.731.81
Principles of Genetic Epidemiology
Location
Internet
Term
1st Term
Department
Epidemiology
Credit(s)
4
Academic Year
2012 - 2013
Instruction Method
TBD
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
No
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Wen Hong Linda Kao
Contact Name
Frequency Schedule
Every Year
Resources
Prerequisite
Introduction to Online Learning and College-level biology or genetics.
First in a four-term series. Presents fundamental concepts and methods in genetic epidemiology. Reviews basic terminology of genetics, introduces basic principles of population genetics, and provides an overview of various genetic epidemiology study designs, covering basic analysis, inferences, plus their strengths and limitations. Presents methods for assessing familial aggregation/correlation, and covers statistical techniques for modeling inheritance of complex phenotypes on family data. Presents both linkage and association analyses, with emphasis on how these are used in genetic epidemiology. Explains different study designs commonly used in genetic epidemiology to identify the genetic basis of common, complex diseases.
Learning Objectives
Upon successfully completing this course, students will be able to:
- Present fundamental concepts and methods in genetic epidemiology
- Discuss and give examples of different types of study designs used in the field of genetic epidemiology
- Discuss and give examples of different types of study designs used in the field of genetic epidemiology; be familiar with basic terminology in the field of human genetics
- Discuss the basic principles behind major molecular biology techniques, such as PCR, and their applications in genetic epidemiology studies
- Discuss various exposures, or markers, used in genetic epidemiology studies
- Discuss principles of Hardy-Weinberg Equilibrium and be able to estimate allele and genotype frequencies
- Discuss and calculate simple statistics, such as odds ratios and LOD scores
- Discuss the difference between linkage and association studies
- Discuss the difference between family-based and population-based studies
- Discuss the difference between direct and indirect association studies
- interpret results of a linkage study
- interpret results of an association study
- select an appropriate study design for addressing a particular question
- Discuss the inferences drawn from the different genetic epidemiology studies