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120.861.01 SPECIAL TOPICS IN BIOCHEMISTRY: X-RAY CRYSTALLOGRAPHY-A HANDS ON WORKSHOP

Term: Summer term
Credits: 3 credits
Contact: Juergen Bosch
Academic Year: 2013 - 2014
Course Instructor:
  • Juergen Bosch
Description:

Enables students to carry out all key steps to successfully solve and refine a protein crystal structure. Theoretical aspects are followed by application to various problem sets. Topics include tricks for data collection, data processing and collection. Touches upon all standard techniques such as molecular replacement, SAD phasing and MAD phasing, both in theory and then applied in practical context with previously collected data. Identification of unknown ligand densities and model refinement lead to the last part of preparing publication quality figures using PyMol.

Learning Objective(s):

Information not required for this course type


Methods of Assessment: Students are evaluated on their participation in classroom discussions and also on completion of assigned homework and tutorial data.
Location: East Baltimore
Class Times:
  • Mon 08/05/2013 - Tue 08/13/2013
  • Monday 8:30 - 5:00
  • Tuesday 8:30 - 5:00
  • Wednesday 8:30 - 5:00
  • Thursday 8:30 - 5:00
  • Friday 8:30 - 5:00
  • Mon 08/05/2013 - Tue 08/13/2013
  • Monday 8:30 - 5:00
  • Tuesday 8:30 - 5:00
Enrollment Minimum: 3
Enrollment Maximum: 20
Enrollment Restriction: None
Instructor Consent: Consent required for all students

Permission of instructor required.

For consent, contact: jubosch@jhsph.edu
Prerequisite:

Some basic knowledge of UNIX or Linux is desirable.

Auditors Allowed: Yes, with instructor consent
Grading Restriction: Letter Grade or Pass/Fail
Special Comments: Students can visit http://lupo/jhsph.edu/boschlab/Xray_Workshop.html for updated information about the course.