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120.861.01 SPECIAL TOPICS IN BIOCHEMISTRY: X-RAY CRYSTALLOGRAPHY-A HANDS ON WORKSHOP

Department:
Biochemistry and Molecular Biology
Term:
Summer term
Credits:
3 credits
Academic Year:
2012 - 2013
Location:
East Baltimore
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Juergen Bosch
Course Instructor:
  • Juergen Bosch

Course Evaluation

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Description:

Enables students to carry out all key steps to successfully solve and refine a protein crystal structure. Theoretical aspects are followed by application to various problem sets. Topics include tricks for data collection, data processing and collection. Touches upon all standard techniques such as molecular replacement, SAD phasing and MAD phasing, both in theory and then applied in practical context with previously collected data. Identification of unknown ligand densities and model refinement lead to the last part of preparing publication quality figures using PyMol.

Methods of Assessment:

Students are evaluated on their participation in classroom discussions and also on completion of assigned homework and tutorial data.

Enrollment Restriction:

None

Instructor Consent:

Consent required for all students

Consent Note:

Permission of instructor required.

For consent, contact:

jubosch@jhsph.edu