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120.626.01 PRINCIPLES OF CELL BIOLOGY

Term: 3rd term
Credits: 3 credits
Contact: Michael Matunis
Academic Year: 2012 - 2013
Course Instructor:
Description:

Provides students with a basic understanding of the architecture and function of eukaryotic cells. In addition to introducing students to new facts and vocabulary pertinent to cell biology, also introduces students to experimental methods used by scientists to define and understand cell structure and function. Highlights relationships between defects in basic cell function and human diseases.

Learning Objective(s):
Upon successfully completing this course, students will be able to:
Identify the intracellular organelles of eukaryotic cells and describe their functions
Design experiments to study individual proteins by light or electron microscopy
Design experiments to fractionate and characterize different membrane-bound organelles
Describe the proteins and mechanisms regulating ion and small molecule transport across membranes
Define the functions of the ER and the mechanisms regulating ER translocation and protein modification within the ER
Design and interpret experiments aimed at studying protein sorting and translocation into sub-cellular organelles
Describe the molecules and mechanisms regulating vesicular transport and protein secretion
Design experiments to study protein transport and targeting in the endocytic pathway
Describe the molecules and pathways involved in relaying signals from the cell surface to the nucleus
Describe the structures and properties of the major proteins that make up the cytoskeleton and their individual functions
Describe the dynamics of actin assembly and the mechanisms of actin-myosin based movement
Describe the dynamics of microtubule assembly and the mechanisms of actin- myosin based movement
Define the structure and function of intermediate filaments
describe the structures and functions of the major molecules mediating cell-cell interactions and tissue formation

Methods of Assessment: There will be a total of 15 short in-class exams. Final course grades will be determined based on the average score of the 14 highest exam scores (the lowest score from the 15 exams will be excluded from the final evaluation).
Location: East Baltimore
Class Times:
  • Wednesday 1:30 - 2:50
  • Friday 1:30 - 2:50
Enrollment Minimum: 10
Instructor Consent: No consent required
Prerequisite:

Introductory courses in Genetics and/or Molecular and Cell Biology (such as 120.602). Students should also have a basic understanding of molecular genetics (i.e. the roles of DNA and RNA in protein synthesis) and a basic understanding of protein structure and function.

Auditors Allowed: Yes, with instructor consent
Grading Restriction: Letter Grade or Pass/Fail