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120.621.01 MOLECULAR ENDOCRINOLOGY

Term: 3rd term
Credits: 4 credits
Academic Year: 2012 - 2013
Course Instructor:
Description:

Presents molecular biology as applied to endocrinology. Topics include the molecular biology and endocrinology of sexual differentiation, hypothalamic and pituitary regulation, ovarian follicular development, steroidogenesis, breast and prostate cancer, androgen, estrogen and thyroid hormone action, diabetes and insulin action, endocrine effects on immunity, G-protein coupled receptors and hormonal regulation of gene expression. Examines steroid and peptide hormone action via paracrine, autocrine, and endocrine mechanisms; transmembrane and intracellular signal transduction; and regulation of nuclear gene transcription.

Learning Objective(s):
Upon successfully completing this course, students will be able to:
Explain the molecular mechanisms by which steroid hormones activate nuclear receptors to provoke their biological effects
Explain the molecular mechanisms by which peptide hormones activate cell surface receptors to provoke their biological effects
Describe how androgens and estrogens are involved in cancers, as in the prostate and breast respectively
Explain how the actions of peptide hormones (e.g. insulin) are involved in diseases (e.g. diabetes)
Construct pathways of the endocrine systems that link control and production of hormones in specific tissues with the actions of these hormones in their respective target organs

Methods of Assessment: Student evaluation based upon class participation, short on-line quizzes related to assigned readings from the current literature, a written mini-review based upon student selected papers from the current literature, and two examinations (mid-term &final)
Location: East Baltimore
Class Times:
  • Tuesday 3:30 - 4:50
  • Thursday 3:30 - 4:50
Enrollment Minimum: 4
Instructor Consent: No consent required
Grading Restriction: Letter Grade or Pass/Fail