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Course Catalog

120.608.01 GENOMICS FOR PUBLIC HEALTH

Department:
Biochemistry and Molecular Biology
Term:
4th term
Credits:
3 credits
Academic Year:
2014 - 2015
Location:
East Baltimore
Class Times:
  • Tu Th,  1:30 - 2:50pm
Lab Times:
  • Tu Th,  1:30 - 2:50pm
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Scott Bailey
Course Instructors:

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Prerequisite:

A college level course in biology.

Description:

Introduces genomics and modern genetic technologies, emphasizing their application to significant public health problems. Designed to be accessible students who have limited prior coursework in molecular biology or molecular genetics. Topics include fundamental principles of molecular biology; genome structure and analysis; mapping of human disease genes; use of microarrays, and next-generation DNA sequencing methodologies in analysis and treatment of human disease; comparative genomics of organisms; epigenomics; metagenomics. Student projects address current issues and controversies in the field, including personalized medicine, genetically modified organisms, and validity vs. lack thereof of patents of genetic or other biologically based material and use of such materials in health assessment and healthcare.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Describe the organization of the human genome
  2. Explain how human disease genes are mapped
  3. Explain how DNA microarrays, protein microarrays, and rapid whole-genome-sequencing technologies can be used to analyze or treat human disease in individuals and populations
  4. Describe basic recombinant DNA, proteomic, and biotechnological methodologies used in the analysis of human disease
  5. Explain how modifications to or organization of chromatin can impact expression of selected human genes
  6. Explain how gut microflora can impact expression of selected human genes
  7. Explain how CRISPR-Cas technology has influenced genome editing
  8. Describe current approaches for gene therapy
Methods of Assessment:

Student evaluation based on:

Online open book quizzes, each quiz covering 1-2 class sessions (20%)
Online, open book cumulative exam in Week 6 of the term (30%)
Team project presentations (in class sessions in Weeks 7-8 of the term) (20%)
Individual op-ed essay on student's own project topic (15%)
Essay on one of two specific class sessions (15%)

Instructor Consent:

No consent required