Biology of Healthy Aging Program
Overview
Ongoing Projects
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Key Findings/Program Goals

Inflammation

• Found strong associations between frailty and cytokines, WBC, neutrophils, and monocytes at population level
• Found that frail PMC’s secreted more IL-6 in response to LPS (human study)
• Connected basic science pathways to findings (NFkB biology)

Next Steps: Biology

• Use mouse models to study causality and interventions for frailty and anemia of inflammation
• Use genetic data to explore transcriptional pathways that accelerate late-life decline and chronic illnesses

Next Steps: Clinical Translation

• Test and implement frailty screening for risk assessment
• Test biomarkers of frailty as risk assessment tools in older adults
• Develop targeted interventions for specific dysregulated systems
• Characterize age-related biological changes in late-life vulnerability
  
  • Late life immune system dysregulation
  • Impact of chronic inflammation on multiple system
  • Role of chronic viral infections on frailty and vaccine response