Faculty - Center on Aging and Health

Qian-Li Xue
Assistant Professor
Biostatistics Director, Center on Aging and Health

Academic Degrees
PhD The Johns Hopkins University, 2000

Departmental Affiliation
Epidemiology

Joint Departmental Affiliations
Biostatistics

Departmental Address
2024 E. Monument Street
Suite 2-700

Email: qxue@jhsph.edu

Phone: 410-502-7808
Fax: 410-614-9625

Research and Professional Experience

My primary area of statistical expertise is the development and application of statistical methods for (i) handling truncation of information on underlying or unobservable outcomes (e.g., disability) as a result of screening, (ii) missing data including outcome (e.g. frailty) censoring by a competing risk (e.g. mortality), and (iii) trajectory analysis of multivariate outcomes. Other areas of methodologic research interests include multivariate, latent variable models.

In Women's Health and Aging Studies, I have closely collaborated with scientific investigators on the design and analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation, and micronutrient deficiencies to the development and progression of frailty and disability, as well as characterizing the natural history of change in cognitive and physical function over time.

Keywords

Epidemiology,Epidemiological design; latent variable; longitudinal data; measurement error; missing data; multivariate categorical data

Honors and Awards

2000 Student Paper Award from the International Biometrics Society Eastern North American Region

2007 Travel Award, Conference on Biomarkers of Aging, American Federation of Aging Research

Selected Publications

Fried LP, Xue Q-L, Cappola A, Chaves PHM, Ferrucci L, Leng S, Semba RD, Varadhan R, Walston JD, Bandeen-Roche K. Multisystem physiologic abnormalities in frailty: evidence for nonlinear system biology at the macro level. J Gerontol A Biol Sci Med Sci. in press.

Carlson MC, Xue Q-L, Zhou J, Fried LP. Declines and deficits in executive function precede those in memory in high-functioning older women: The Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):110-7.

Cappola AR, Xue Q-L, Fried LP. Multiple Hormonal Deficiencies in Anabolic Hormones Are Found in Frail Older Women: The Women's Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2009 Feb; 64(2):243-8.

Xue Q-L, Bandeen-Roche K, Zhou J, Varadhan R, Fried LP. Initial manifestations of frailty criteria and the development of frailty phenotype in the Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008; 63(9): 984–990.

Xue Q-L, Fried LP, Glass TA, Laffan AM, Chaves PHM. Life-Space Constriction, Development of Frailty, and the Competing Risk of Mortality: The Women’s Health and Aging Study I. Am J Epidemiol. 2008; 167(2):240-48.

Leng SX, Xue Q-L, Tian J, Walston JD, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc. 2007; 55(6):864-71.

Barzilay JI, Blaum C, Moore T, Xue Q-L, Hirsch CH, Walston JD, Fried LP. Insulin resistance and inflammation as precursors of frailty: The Cardiovascular Health Study. Arch Intern Med. 2007; 167:635-641.

Stewart R, White LR, Xue Q-L, Launer LJ. 26-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol. 2007; 64:103-107.

Jerome GF, Glass TA, Mielke M, Xue Q-L, Andersen RE, Fried LP. Physical Activity Participation by Presence and Type of Functional Deficits in Older Women: The Women's Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1171-6.

Semba RD, Ferrucci L, Cappola AR, Ricks MO, Ray AL, Xue Q-L, Guralnik, JM, Fried LP. Low Serum Selenium Is Associated with Anemia Among Older Women Living in the Community: the Women's Health and Aging Studies I and II. Biol Trace Elem Res. 2006;112(2):97-107.

Tan EJ, Xue Q-L, Li T, Carlson MC, Fried LP. Volunteering: a Physical Activity Intervention for Older Adults - The Experience Corps Program in Baltimore. J Urban Health. 2006; 83(5):954-69.

Cappola AR, Xue QL, Walston JD, Leng SX, Ferrucci L, Guralnik J, Fried LP, DHEAS Levels and Mortality in Disabled Older Women: The Women's Health and Aging Study I. J Gerontol A Biol Sci Med Sci. 2006;61(9):957-62.

Arking DE, Fallin MD, Fried LP, Li T, Beamer BA, Xue Q-L, Chakravarti A, Walston J. Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women. J Am Geriatr Soc. 2006;54(5):823-6.

Lin SM, Xue Q-L, Simonsick EM, Tian J, Bandeen-Roche K, Fried LP, Bathon JM.(2006) Transitions to Mobility Difficulty Associated with Lower Extremity Osteoarthritis (OA) in High Functioning Older Women: Longitudinal data from the Women’s Health and Aging Study II. Arthritis Rheum.;55(2):256-63.

Ray AL, Semba RD, Walston J, Ferrucci L, Cappola AR, Ricks MO, Xue Q-L, Fried LP. (2006) Low serum selenium and total carotenoids predict mortality among older women living in the community: the Women’s Health and Aging Studies. The Journal of Nutrition; 136(1):172-6

Bandeen-Roche, K., Xue, Q-L., Ferrucci, L., Walston, J., Guralnik, J.M., Fried, L.P. (2006) Phenotype of Frailty: characterization in the Women’s Health and Aging Studies. Journal of Gerontology: Medical Sciences; 61(3):262-6.

Walston, J., Xue, Q-L., Semba, R.D., Ferrucci, L., Cappola, A.R., Ricks, M., Guralnik, J., Fried, L.P. Serum antioxidants, inflammation, and mortality in older women. American Journal of Epidemiology; 163(1):18-26.

Leng, S.X., Xue, Q-L., Huang, Y., Ferrucci, L., Beamer, B.A., Fried, L.P., Walston, J.D. (2005) Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older women. Experimental Gerontology; 40(12):982-987.

Semba, R.D., Blaum, C.S., Xue, Q-L., Ricks, J.M., Guralnik, J.M., and Fried, L.P. Denture use, undernutrition, and frailty among older women living in the community. The Journal of Nutrition, Health and Aging, 10(2):161-7.

Blaum CS, Xue Q-L, Michelon E, Semba RD, and Fried LP. The association of obesity and the frailty syndrome in older women. The Journal of the American Geriatrics Society 2005; 53(6):927-34.

Windhan BG, Griswold ME, Fried LP, Rubin, GS, Xue Q-L, Carlson MC. (2005) Impaired Vision and the Ability to Take Medications. The Journal of the American Geriatrics Society;53(7):1179-90.

Boyd C, Xue Q-L, Simpson, CF, Guralnik, JM, Fried, LP. Frailty, hospitalization and progression of disability in a cohort of disabled older women: The Women’s Health and Aging Study I. (2005) The American Journal of Medicine; 118(11):1225-31.

Boyd C, Xue Q-L, Guralnik JM, Fried LP. (2005) Hospitalization and Development of Dependence in Activities of Daily Living in a Cohort of Disabled Older Women: The Women's Health and Aging Study I. Journal of Gerontology: Medical Sciences 2005; 60(7):888-93.

Walston J, Arking DE, Fallin D, Li T, Beamer B, Xue Q-L, Rabins P, Ferrucci L, Fried LP, Chakravarti A. IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women. Experimental Gerontology 2005; 40:344-352.

Stewart R, Masaki K, Xue Q-L, Peila R, Petrovitch H, White LR, and Launer LJ A 32-year prospective study of change in body weight and incident dementia. The Honolulu-Asia Aging Study. Archives of Neurology 2005; 62(1):55-60.

Carlson MC, Fried LP, Xue Q-L, Tekwe C, and Brandt J. Validation of the Hopkins medication schedule to identify difficulties in taking medications. Journal of Gerontology: Medical Sciences 2005; 60A(2):217-223.

Schmaltz HN, Semba RD, Xue Q-L, Walston J, Leng S, and Fried LP. Latent cytomegalovirus infection and inflammation are associated with prevalent frailty among community-dwelling older women. The Journal of the American Geriatrics Society 2005; 53(5):747-54.

Michelon E, Blaum C, Semba RD, Xue Q-L, Ricks MO, and Fried LP. Vitamin and carotenoid status in older women: associations with the frailty syndrome. J Gerontol A Biol Sci Med Sci. 2006;61(6):600-7.

Leng S, Xue Q-L, Huang Y, Semba R, Chaves PHM, Fried LP, and Walston J. Total and differential white blood cell counts and their associations with circulating interleukin-6 levels in community-dwelling older women. Journal of Gerontology: Medical Sciences 2005; 60A(2):195-199.

Blaum CS, Volpato S, Cappola A, Chaves PHM, Xue Q-L, Guralnik JM, Fried LP. Diabetes, excess hyperglycemia, and mortality in disabled older women: The Women’s Health and Aging Study I. Diabetic Medicine 2005, 22(5):543-50.

Chaves PHM, Xue Q-L, Guralnik JM, Ferrucci L, Volpato S, Fried LP. What constitutes normal hemoglobin concentration in community-dwelling disabled older women? The Journal of the American Geriatrics Society 2004; 52:1-6.

Cappola AR, Xue Q-L, Ferucci L, Guralnik JM, Volpato S, and Fried LP. Insulin-Like Growth Factor –1 and Interleukin-6 Contribute to disability and mortality in older women. The Journal of Clinical Endocrinology & Metabolism 2003; 88(5):2019-2025.

Xue Q-L, Bandeen-Roche K. Combining complete multivariate outcomes with incomplete covariate information: a latent class approach. Biometrics 2002; 58: 66-76.

Seibert M, Xue Q-L, Walston J. Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the Women’s Health and Aging Study II cohort. Journal of American Geriatrics Society 2001; 49: 1-4.

Carlson MC, Fried LP, Xue Q-L, Bandeen-Roche K, Zeger SL, Brandt J. Cognitive predictors of pre-clinical functional difficulties in older women. Journal of Gerontology: Social Sciences 1999; 54B-5, S262-S270.